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Xiaofeng Deng Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haoran Xu Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoxia Hao Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jiawei Liu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xingru Shang Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Tao Xu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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7. Coryell PR Diekman BO Loeser RF . Mechanisms and therapeutic implications of cellular senescence in osteoarthritis . Nature Reviews. Rheumatology 2021 17 47 – 57 . ( https://doi.org/10.1038/s41584-020-00533-7 ) 33208917 8. van den Bosch

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Mohammad Shahid St Michael’s Hospital, 30 Bond Street, Toronto, M5B1W8, Canada
Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK

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Rik Kundra St Michael’s Hospital, 30 Bond Street, Toronto, M5B1W8, Canada
Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK

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facilitate tissue healing. 8 PRP owes its therapeutic use to the limited evidence that growth factors released by the platelets possess multiple regenerative properties. 9 Tissue repair is a complex process comprising chemotaxis, angiogenesis, cell

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E. Carlos Rodríguez-Merchán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Hortensia De la Corte-Rodríguez Department of Physical and Rehabilitation Medicine, La Paz University Hospital, Madrid, Spain

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Carlos A. Encinas-Ullán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Following multiligamentous knee reconstructions, the postoperative rehabilitation protocol is important for therapeutic success. This protocol should be slower than when an isolated ACL reconstruction is performed. Stretching of the graft during

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Hélder Pereira Orthopedic Department of Póvoa de Varzim - Vila do Conde Hospital Centre, Vila do Conde, Portugal
Ripoll y De Prado Sports Clinic, Murcia-Madrid, FIFA Medical Centre of Excellence, Madrid, Spain
International Centre of Sports Traumatology of the Ave, Vila do Conde, Portugal
3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Ibrahim Fatih Cengiz 3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal

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Sérgio Gomes International Centre of Sports Traumatology of the Ave, Vila do Conde, Portugal

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João Espregueira-Mendes 3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clínica do Dragão, Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal
Orthopedic Department, University of Minho, Braga, Portugal

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Pedro L. Ripoll Ripoll y De Prado Sports Clinic, Murcia-Madrid, FIFA Medical Centre of Excellence, Madrid, Spain

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Joan C. Monllau Orthopaedic Department, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain

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Rui L. Reis 3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal

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J. Miguel Oliveira 3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Orthopaedic Department, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal

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One should bear in mind the basic science knowledge related to each meniscus since it surely has implications for tissue loss, repair, healing and outcomes of replacement. 12 , 17 Moreover, vascularization of the menisci is critical for treatment

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