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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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B Chisari E et al. The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine . BioMed Res Int 2018 ; 2018 : 7402947 . 26. Filardo G Kon

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Julien Favre Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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Brigitte M. Jolles Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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contributing to the burden of knee OA is the absence of a cure. Current therapeutic options consist primarily of medication and rehabilitation to reduce symptoms, and of arthroplasty later in the disease, when the joint becomes too severely damaged

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Lei Yao Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Jie Cai West China School of Medicine, Sichuan University, Chengdu, Sichuan, China

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Junqiao Li Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Yan Xiong Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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Jian Li Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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articular cartilage and their implications on arthroscopic procedures: a review of literature . Journal of Clinical Orthopaedics and Trauma 2020 11 ( Supplement 3 ) S396 – S401 . ( https://doi.org/10.1016/j.jcot.2019.06.017 ) 5 Bulstra SK Kuijer R

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Pietro Feltri Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Camilla Mondini Trissino da Lodi Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Alberto Grassi II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Stefano Zaffagnini II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Christian Candrian Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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Giuseppe Filardo Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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another important element to be considered for the direct implications in anaesthesia-related risks and costs. 43 Due to the lack of data of the retrieved studies about the cost aspect, we did not perform a specific economic analysis on costs between

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Anoop K. Prasad Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Jaimee H.S. Tan Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Hany S. Bedair Department of Orthopaedics, Massachusetts General Hospital, Boston, Massachusetts, USA
Kaplan Joint Center, Department of Orthopaedics, Newton-Wellesley Hospital, Newton, Massachusetts, USA

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Sebastian Dawson-Bowling Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Sammy A. Hanna Department of Trauma and Orthopaedic Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK

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Clin Orthop Trauma 2013 ; 4 : 157 – 163 . 24. Khanna G Cernovsky J . Bone cement and the implications for anaesthesia . Contin Educ Anaesth Crit Care Pain 2017 ; 12 : 213 – 216 . 25. Gallo J

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Sebastian Kopf Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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Manuel-Paul Sava Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania

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Christian Stärke Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany

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Roland Becker Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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system, including the pro-inflammatory pathway. 23 Another definition proposed by the American College of Rheumatic and Therapeutic Criteria states that OA is a group of conditions that are heterogenic, which advances to joint-related symptoms and

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Tommaso Bonanzinga IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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Pietro Conte IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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Giuseppe Anzillotti IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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Vincenzo Longobardi IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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Elizaveta Kon IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia

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Maria Rescigno IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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Maurilio Marcacci IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy

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. ( https://doi.org/10.1002/art.41210 ) 35 Fernández-Rodríguez D Baker CM Tarabichi S Johnson EE Ciccotti MG & Parvizi J . Mark Coventry Award: human knee has a distinct microbiome: implications for periprosthetic joint infection . Journal

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