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Signe Steenstrup Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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Niels Martin Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark

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Per Hviid Gundtoft Department of Orthopedic Surgery and Traumatology, Aarhus University Hospital, Aarhus, Denmark

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Søren Kold Department of Orthopedic Surgery, Aalborg University Hospital, Aalborg, Denmark

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Robert Zura Department of Orthopedic Surgery, Louisiana State University Medical Center, New Orleans, Louisiana, USA

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Bjarke Viberg Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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work ( 1 , 2 , 3 , 4 ). Early identification of nonunion is therefore important and one possibility is to identify risk factors. This could result in earlier recognition of patients at risk, leading to closer follow-up and lowering the threshold for

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Vanessa Morello Division of Orthopaedic and Trauma Surgery, University Hospitals of Geneva, Geneva, Switzerland

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Axel Gamulin Division of Orthopaedic and Trauma Surgery, University Hospitals of Geneva, Geneva, Switzerland

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intubated, sedated or obtunded patients. In this perspective, red flags or predictors need to be recognized ( 45 , 46 ). When present, these risk factors should lead the physician in charge to perform frequent clinical assessments and/or repeated or

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Duy Nguyen Anh Tran The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Bao Tu Thai Nguyen The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Tan Thanh Nguyen Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Yu-Pin Chen Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Yi-Jie Kuo Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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risk factors ( 15 , 16 , 17 , 18 , 19 , 20 ), the contribution of smoking remains contentious, with conflicting evidence from several studies and meta-analyses ( 14 , 21 , 22 , 23 ). Previous meta-analyses have noted the detrimental influence

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Arvin Eslami Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
Firoozgar Hospital, Bone and Joint reconstruction research center, Iran University of Medical Sciences, Tehran, Iran
Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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Mohammadreza Chehrassan Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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Shaya Alimoghadam Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
Firoozgar Hospital, Bone and Joint reconstruction research center, Iran University of Medical Sciences, Tehran, Iran
Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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Karim Pisoudeh Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
Firoozgar Hospital, Bone and Joint reconstruction research center, Iran University of Medical Sciences, Tehran, Iran
Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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Amir Kasaeian Digestive Oncology Research Center, Digestive Diseases Research Institute; Research Center for Chronic Inflammatory Diseases; Clinical Research Development Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Omid Elahifar Bone and Joint reconstruction research center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
Firoozgar Hospital, Bone and Joint reconstruction research center, Iran University of Medical Sciences, Tehran, Iran
Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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patient mortality, irrespective of underlying conditions. This risk is notably exacerbated in pregnant women that potentially elevate the likelihood of fatality ( 1 , 5 , 8 , 9 , 10 , 11 , 12 , 13 ). Regarding the fetus, factors such as placental

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Luca Pacchiarini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Lorenzo Massimo Oldrini Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Pietro Feltri Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Stefano Lucchina Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Surgical Department, Hand Surgery Unit EOC, Locarno’s Regional Hospital, Locarno, Switzerland
Locarno Hand Center, Locarno, Switzerland

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Giuseppe Filardo Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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Christian Candrian Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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. Furthermore, from the studies reviewed, it is not possible to stratify patients by age, sex, or comorbidities; it may be important to understand whether there are certain risk factors that lead to more complications, to provide clearer information to patients

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Julia Riemenschneider Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Jan Tilmann Vollrath Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Nils Mühlenfeld Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Johannes Frank Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Ingo Marzi Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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Maren Janko Department of Trauma-, Hand- and Reconstructive Surgery, Goethe University, Frankfurt, Germany

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arthroplasty (THA) without or with a Burch–Schneider ring and lastly combined treatment methods ( 2 , 22 , 26 , 27 ). The ideal therapy regime is dependent on fracture pattern, individual risk factors and the availability of the treatment method in the

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Mabua A. Chuene Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa

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Jurek R.T. Pietrzak Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa

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Allan R. Sekeitto Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa

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Lipalo Mokete Arthroplasty Unit, CMJAH, University of the Witwatersrand, Johannesburg, South Africa

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group on PPIs n = 139 had AGIH. 3 (1.1%) in interventional group not on PPIs n = 276 had AGIH their risk factors were missed. Prophylactic use of proton pump inhibitors in patients with risk factor for acute gastrointestinal haemorrhage

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Mario Herrera-Pérez Foot and Ankle Unit, Orthopaedic Department, Hospital Universitario de Canarias, Tenerife, Spain
School of Medicine, Universidad de La Laguna, Tenerife, Spain

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Pablo Martín-Vélez Foot and Ankle Unit, Orthopaedic Department, Hospital Universitario de Canarias, Tenerife, Spain

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David González-Martín Foot and Ankle Unit, Orthopaedic Department, Hospital Universitario de Canarias, Tenerife, Spain
School of Medicine, Universidad de La Laguna, Tenerife, Spain

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Miguel Domínguez-Meléndez Foot and Ankle Unit, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain

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Ahmed E Galhoum Specialty Doctor Trauma and Orthopaedics, George Eliot Hospital NHS Trust, Nuneaton, UK

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Victor Valderrabano Schmerzklinik, Basel, Switzerland
University of Basel, Basel, Switzerland

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Sergio Tejero Foot and Ankle Unit, Hospital Universitario Virgen del Rocío, Sevilla, Spain
School of Medicine, Universidad de Sevilla, Sevilla, Spain

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, 7 , 8 , 9 , 10 , 11 ), especially in frail patients, and, although several risk factors have been described in the literature as predictors of adverse effects after ankle ORIF ( 12 ), no specific inclusion criteria have been identified to opt for

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Christof Audretsch BG Trauma Center, Department for Traumatology and Reconstructive Surgery, University of Tübingen, Tübingen, Germany

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Alexander Trulson BG Trauma Center, Department of Trauma Surgery, Murnau am Staffelsee, Germany

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Andreas Höch Department of Orthopedics, Trauma and Plastic Surgery, University of Leipzig, Leipzig, Germany

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Steven C Herath BG Trauma Center, Department for Traumatology and Reconstructive Surgery, University of Tübingen, Tübingen, Germany

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Tina Histing BG Trauma Center, Department for Traumatology and Reconstructive Surgery, University of Tübingen, Tübingen, Germany

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Markus A Küper BG Trauma Center, Department for Traumatology and Reconstructive Surgery, University of Tübingen, Tübingen, Germany

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Working Group on Pelvic Fractures of the German Trauma Society
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comminution in posterior wall fractures in particular have been identified as a risk factor for a poor functional outcome ( 12 ), which in turn can result in a recommendation for surgical treatment of comminuted posterior wall fractures. On the other hand

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Benedikt Johannes Braun Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Jörg Holstein Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Tobias Fritz Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Nils Thomas Veith Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Steven Herath Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Philipp Mörsdorf Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Tim Pohlemann Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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as no physiological symptoms of anaemia are present. 15 However, these physiological symptoms of volume depletion are not always present in the polytraumatised patient and careful consideration of the accompanying risk factors (such as low

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