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Maria A. Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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Dimosthenis Andreou Department of General Orthopaedics and Tumour Orthopaedics, University Hospital Muenster, Germany

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Per-Ulf Tunn Tumour Orthopaedics, HELIOS Klinikum Berlin-Buch, Germany

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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objective of the present review was to identify all major studies dealing with endoprosthetic reconstruction in tumour surgery published between January 2015 and 10 June 2018. The specific focus was on long-term results and functional outcome, complications

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James Plant Royal National Orthopaedic Hospital, Stanmore, UK

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Stephen Cannon Royal National Orthopaedic Hospital, Stanmore, UK

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Society . The hazards of the biopsy, revisited . J Bone Joint Surg [Am] 1996 ; 78 : 656 - 63 . 11 Stoker DJ , Cobb JP , Pringle JAS . Needle biopsy of musculoskeletal lesions. A review of 208 procedures . J Bone

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Stephanie Marrannes Department of Orthopedic Surgery, Ghent University, Belgium

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Klaas Victor Department of Orthopedic Surgery, University of Leuven, Belgium

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Nele Arnout Department of Orthopedic Surgery, Ghent University, Belgium

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Tine De Backer Department of Cardiology, Ghent University, Belgium

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Jan Victor Department of Orthopedic Surgery, Ghent University, Belgium

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Thomas Tampere Department of Orthopedic Surgery, Ghent University, Belgium

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are its low cost and convenient, oral administration without need for routine blood monitoring. 2 , 20 – 22 Several systematic reviews have attempted to summarize the evidence on aspirin thromboprophylaxis following lower limb orthopaedic surgery. 1

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Joaquim Soares do Brito Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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André Spranger Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Paulo Almeida Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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José Portela Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Irene Barrientos-Ruiz Orthopedics Department, University Hospital of La Paz, Madrid

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metastatic disease does not lead to patient’s death. 10 , 11 Methods This study is a systematic review of published studies in the English-language literature concerning the outcomes obtained with surgical treatment of GCTs of bone located around

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Andrea Angelini Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Ivan Bohacek Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Mihovil Plecko Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Carlo Biz Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Mariachiara Cerchiaro Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giuseppe Di Rubbo Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review has been registered on the International Prospective Register of Systematic Reviews (PROSPERO). Two reviewers (MP, IB) performed a

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Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Joanna Szkandera Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Graz, Austria

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Dimosthenis Andreou Division of Orthopaedic Oncology and Sarcoma Surgery, Helios Klinikum Bad Saarow, Sarcoma Center Berlin-Brandenburg, Berlin, Germany

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Emanuela Palmerini Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy

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Marko Bergovec Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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variable treatment responses, however, therapeutic approaches for different subtypes may significantly differ. Therefore, the aim of the present systematic review was to summarize recent knowledge on treatment of patients with locally advanced

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Serkan Bayram Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Salduz Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Müçteba Yıldırım Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Korhan Özkan Department of Orthopedics and Traumatology, Istanbul Medeniyet University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Levent Eralp Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Harzem Özger Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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strategy This study was performed according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) ( 11 , 12 ). All electronic searches were performed on November 20, 2022, by a single researcher who

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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): 2676 – 2680 . doi: 10.1093/annonc/mdt252 7. Wang W Yeung KWK . Bone grafts and biomaterials substitutes for bone defect repair: A review . Bioact Mater 2017 ; 2 ( 4 ): 224 – 247 . doi: 10.1016/j.bioactmat.2017

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Stijn E. W. Geraets Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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P. Koen Bos Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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Johan van der Stok Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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However, there is no consensus in the guidelines or literature as to which types of long bone metastasis benefit from preoperative embolization in order to reduce blood loss. The primary aim of this systematic review was to identify long bone metastases

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Maria Beatriz Quaresma Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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José Portela Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Joaquim Soares do Brito Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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and improve function, with the potential for concomitantly higher morbidity and reduced quality of life. 8 – 11 With all these findings under consideration, the authors present here our findings from the literature and a systematic review

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