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Pengqiang Lou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Guangzhi Zhou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Bo Wei Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Xiaolei Deng Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Decai Hou Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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article provides a review of the pathophysiology of the sclerotic zone in femoral head necrosis, the formation process, and the impact on femoral head necrosis. Pathology of femoral head necrosis and sclerotic zone formation The death of bone

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Pieter Bas de Witte Department Orthopedic Surgery, LUMC, Leiden, the Netherlands

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Christiaan J A van Bergen Department Orthopedic Surgery, Amphia, Breda, the Netherlands

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Babette L de Geest Knowledge Institute of Medical Specialists, Utrecht, the Netherlands

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Floor Willeboordse Knowledge Institute of Medical Specialists, Utrecht, the Netherlands

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Joost H van Linge Juliana Children’s Hospital, The Hague & Reinier HAGA Orthopaedic Centre, Zoetermeer and Delft, the Netherlands

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Yvon M den Hartog Department Orthopedic Surgery, MST, Enschede, the Netherlands

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Magritha (Margret) M H P Foreman-van Drongelen Department Hip Sonography, Diagnostiek voor U, Eindhoven, The Netherlands

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Renske M Pereboom Dutch Hip Patient Association “Vereniging Afwijkende Heupontwikkeling”, Nijkerk, the Netherlands

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Simon G F Robben Department Radiology, Maastricht University Medical Center, Maastricht, the Netherlands

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Bart J Burger Department Orthopedic Surgery, North West Hospital Group, Alkmaar, the Netherlands

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M Adhiambo Witlox Department Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, the Netherlands

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Melinda M E H Witbreuk Department Orthopedic Surgery OLVG, AUMC Amsterdam, the Netherlands

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E = 86.2%, G= 13.8% Ia = 69%, Ib = 24.1%, II = 6.9% AVN: 48.3%; Other: 5 hips; ( P  = 0.029) AI, acetabular index; PCS, prospective cohort study; RCCS, retrospective comparative cohort study; RCRS, retrospective chart review study

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David Lin Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Alexander Charalambous Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Sammy A. Hanna Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Arthroplasty on a single side alone will not restore mobility and independence to this group of patients. There is, however, scarce data published regarding the outcome of bilateral THA in this group of patients. We performed a systematic review of the

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Yun Yang Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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Yin-xiao Peng Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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Bin Yu Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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versions were available. The references of the selected articles were also reviewed to identify other valuable articles. A total of 22 articles were included in this review. ( Fig. 1 ). The review process was conducted according to the Preferred Reporting

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Eustathios Kenanidis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece
Hôpital de la Tour, Geneva, Switzerland

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Konstantinos Kapriniotis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panagiotis Anagnostis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Michael Potoupnis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panayiotis Christofilopoulos Hôpital de la Tour, Geneva, Switzerland

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Eleftherios Tsiridis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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promise better outcomes. This comprehensive systematic review aims to evaluate the literature in terms of revision rate, functional outcomes, type of implant fixation and complications of THA in patients suffering from SCD-related AVN. Methods

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Mattia Loppini Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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Francesco Manlio Gambaro Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

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Rob G H H Nelissen Landelijke Registratie Orthopedische Implantaten (Dutch Arthroplasty Register), ’s Hertogenbosch, The Netherlands
Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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Guido Grappiolo IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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implants have a limited lifespan, which a recent review by Evans et al. has estimated to be around 20 years for 75% of patients and 25 years for 56% ( 2 ). The gap of knowledge that the present review attempts to fill resides in the lack of clear

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Matthew Barrett Barts and the London School of Medicine & Dentistry, UK

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Anoop Prasad Department of Orthopaedics, Royal London Hospital, UK

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Louis Boyce Barts and the London School of Medicine & Dentistry, UK

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Sebastian Dawson-Bowling Department of Orthopaedics, Royal London Hospital, UK

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Pramod Achan Department of Orthopaedics, Royal London Hospital, UK

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Steven Millington Department of Orthopaedics, Royal London Hospital, UK

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Sammy A. Hanna Department of Orthopaedics, Royal London Hospital, UK

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and non-obese patients. 21 , 22 Despite this, it is common practice for patients with a BMI ≥ 40 kg/m 2 to be asked to provide evidence of weight loss pre-operatively. 20 We performed a comprehensive systematic review of the literature to

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J R W Crutsen Department of Orthopaedic Surgery, VieCuri Medical Center, Venlo, the Netherlands

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M C Koper Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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J Jelsma Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands

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M Heymans Zuyderland Academy, Centre of Knowledge and Information (KIC), Zuyderland Medical Centre, Sittard-Geleen, the Netherlands

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I C Heyligers Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Health Professions Education (SHE), Maastricht University, Maastricht, the Netherlands

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B Grimm Luxembourg Institute Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg

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N M C Mathijssen Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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M G M Schotanus Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands

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at what blood cobalt concentration toxicity occurs. The present study is a systematic review of the current literature reporting systemic cobalt toxicity symptoms after any type of hip arthroplasty. The aim is to define and present the most reported

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Pernille Bovbjerg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Ditte Høgh Department of Orthopedic Surgery, Hospital of Southern Denmark, Odense, Denmark

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Lonnie Froberg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Hagen Schmal Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark
Clinic of Orthopaedic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Moustapha Kassem Department of Endocrinology, Odense University Hospital, Odense, Denmark

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or small studies, including fractures of all types. 7 – 10 The purpose of this systematic review was to investigate whether PTH treatment for insufficiency fractures of the pelvis is more efficient than the current standard of care

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Stavros Tsotsolis Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
Department of Trauma and Orthopaedics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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parameters do not necessarily ensure the longevity and survival of THA. This systematic review aims to thoroughly and critically appraise the available literature evaluating the implant survival and the AL risk of patients receiving BPs after elective THA

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