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James R. Berstock University of British Colombia Department of Orthopaedics, Gordon & Leslie Diamond Health Care Centre, Vancouver, British Columbia, Canada

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Michael R. Whitehouse Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK

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popularity and became the most commonly performed orthopaedic surgery in all countries collecting such data. Subsequent trials that confirmed the findings of the NEJM publication were conducted, published and largely ignored. 2 It took a review of the

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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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, cytoplasmic swelling, and mitochondrial condensation ( 2 , 8 ). In recent years, numerous studies have demonstrated that ferroptosis plays an important role in the progression of OP. This review shows the role of iron metabolism, lipid metabolism, and the

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Pierre J Hoffmeyer Editor-in-Chief, EFORT Open Reviews

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different from what we knew. In light of what was said above, we are proud to say that EOR ( EFORT Open Reviews ) offers an online solution to fill the educational gap. The impact factor of EOR has more than doubled in 1 year going from 2.295 in 2020

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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commercial interest following PRP use in professional sport. 8 This review aims to synopsise PRP use in musculoskeletal pathologies through evidence-based assessment of the preparation, classification systems, mechanism of action and clinical

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Anne Lübbeke Division of Orthopaedic Surgery & Traumatology, Geneva University Hospitals and University of Geneva, Switzerland
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK

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Christophe Combescure Division of Clinical Epidemiology, Geneva University Hospitals and University of Geneva, Switzerland

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Christophe Barea Division of Orthopaedic Surgery & Traumatology, Geneva University Hospitals and University of Geneva, Switzerland

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Amanda Inez Gonzalez Division of Orthopaedic Surgery & Traumatology, Geneva University Hospitals and University of Geneva, Switzerland

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Keith Tucker Chair Orthopaedic Data Evaluation Panel, UK

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Per Kjærsgaard-Andersen Center for Adult Hip and Knee Reconstruction, Department of Orthopaedics, South Danish University, Vejle Hospital, Denmark

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Tom Melvin School of Medicine, Trinity College Dublin, Ireland

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Alan G Fraser Department of Cardiology, University Hospital of Wales, Cardiff, UK

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Rob Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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James A Smith Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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, with a contract required between manufacturers for high-risk devices (MDR Article 61(5)). The peer-reviewed medical literature is an established major source of clinical evidence regarding medical devices ( 1 ). In orthopaedic surgery, information

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Jasmine N. Levesque Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

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Ajay Shah Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

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Seper Ekhtiari Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada

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James R. Yan Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada

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Patrick Thornley Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada

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Dale S. Williams Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada

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increase in the amount of published literature presenting orthopaedic applications of 3D printing. In addition, a number of narrative reviews have provided an overview of the topic. 20 , 21 As well, there is a recent systematic review on the

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Ahmed Halloum Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark

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Søren Kold Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark

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Jan Duedal Rölfing Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark

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Ahmed A Abood Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark
Department of Orthopaedics, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark

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Ole Rahbek Interdisciplinary Orthopaedics, Aalborg University Hospital, Hobrovej, Aalborg, Denmark

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guided growth now has been reported in clinical case series ( 5 , 13 , 14 ) and may appeal to many clinicians as a safe procedure, the aim of this scoping review was to determine the current body of evidence in the literature and to identify possible

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Jean-Charles Aurégan Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.
Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.
Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Catherine Bosser Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Morad Bensidhoum Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Thierry Bégué Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.

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Thierry Hoc Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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in order to fulfil that purpose. To test that hypothesis, we performed a systematic review of every study reporting relationships between skin and bone parameters in women with postmenopausal osteoporosis. Our purpose was to answer the following

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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands

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Bart L Kaptein Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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. Two systematic reviews have previously been conducted, in 2011 and 2014, to assess the feasibility of several biomarkers to differentiate between aseptic loosened and stable implants. However, these reviews did not assess the quality of the included

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Mara Meyer Günderoth Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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Alexandra Bannach-Brown Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany

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Johannes Keller Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Robert Karl Zahn Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Tazio Maleitzke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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for CT-mediated effects in arthritis, which have, however, not yet been analyzed systematically. In light of new pharmacological developments, this systematic review and meta-analysis investigates the therapeutic potential of CT in preclinical OA and

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