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osteosarcomas: results from the PEMBROSARC study . Eur J Cancer 2019 ; 119 : 151 – 157 . 50. Womer RB West DC Krailo MD et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of
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, (3)aspirin prophylaxis was compared to other prophylactic agents, no prophylaxis or if different dosages of aspirin were compared. Both observational studies and randomized controlled trials (RCTs) were included. Only articles published in the last 30
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, were not of high quality. High-quality studies, such as randomized controlled prospective studies and prospective cohort studies are ideal for meta-analyses. Although the studies included in the meta-analysis examined all the factors mentioned above
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No randomized controlled trials were found, the seven articles that were included all were retrospective case-cohort studies, providing an OCEBM score of 3. The MINORS scores ranged from 7 to 13 ( Table 3 ). Primary outcome measures The
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current methods of STS screening are based on an understanding of the condition, available treatments, and worldwide guidelines according to the updated results of the randomized TOSS study and SAFETY trial ( 5 , 6 ); nevertheless, even these guidelines
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JD Yang JC White D . Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial . Ann Surg Oncol 2014 ; 21 : 2484 - 2489 . 77
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A Pignatti G Barbieri E , et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial . Journal of Clinical Oncology 2001 19 1238 – 1247 . ( https://doi.org/10
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-treatment ( 39 , 40 , 41 ). Zoledronic acid, a third-generation bisphosphonate, excels in treating bone metastases in malignancies, including RCC. Supported by three randomized trials ( 42 ), it not only alleviates pain but also extends the time before SREs
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controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma . Cancer 2008 ; 113 : 573 – 581 . 92. Demetri GD von Mehren M Jones RL et al. Efficacy and safety of trabectedin or dacarbazine
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, Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial . Lancet. Oncology 2020 21 60 – 72 . ( https://doi.org/10.1016/S1470-2045(1930687-4 ) 4. Flanagan AM Larousserie F O’Donell PG