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Marko Bumbaširević School of Medicine, University of Belgrade, Serbia
University Clinic for Orthopaedic Surgery and Traumatology, Clinical Centre of Serbia, Serbia

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Aleksandar Lesic School of Medicine, University of Belgrade, Serbia
University Clinic for Orthopaedic Surgery and Traumatology, Clinical Centre of Serbia, Serbia

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Tomislav Palibrk School of Medicine, University of Belgrade, Serbia
University Clinic for Orthopaedic Surgery and Traumatology, Clinical Centre of Serbia, Serbia

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Darko Milovanovic School of Medicine, University of Belgrade, Serbia
University Clinic for Orthopaedic Surgery and Traumatology, Clinical Centre of Serbia, Serbia

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Milan Zoka King’s College Hospital, London, UK

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Tamara Kravić-Stevović University of Belgrade, Department of Histology and Embryology, Serbia

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Stanisa Raspopovic ETH Zürich, Department of Health Sciences and Technology, Institute for Robotics and Intelligent System, Zurich, Switzerland

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Introduction Amputations and, consequently, prostheses as their most immediate solution, have a long history, starting with hooks and other prosthetic replacements of the Middle Ages, continuing to Ambroise Paré’s mechanical hand ( Fig. 1

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Thomas J. Holme Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK

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Marta Karbowiak Royal Surrey NHS Foundation Trust, Trauma & Orthopaedics, Guildford, UK

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Jennifer Clements Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK

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Ritesh Sharma Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK

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Johnathan Craik Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK

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Najab Ellahee Epsom & St Helier University Hospitals NHS Trust, Trauma & Orthopaedics, Carshalton, UK

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prosthetic total joint replacement. Materials and methods Search strategy We conducted an online systematic literature search in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. It was

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Martin McNally The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Irene Sigmund The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria

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Andrew Hotchen The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Ricardo Sousa Porto Bone and Joint Infection Group (GRIP), Department of Orthopaedics, Centro Hospitalar Universitario Santo António and CUF-Hospitais e Clinicas, Portugal

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Introduction Prosthetic joint infection (PJI) has been identified as the second most common cause of revision after knee arthroplasty and the fourth commonest cause in hips, in the United Kingdom ( 1 ). This may be a major underestimation as

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Christoph H. Lohmann Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Sanjiv Rampal Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Martin Lohrengel Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Gurpal Singh Division of Musculoskeletal Oncology, University Orthopaedics Hand and Reconstructive Microsurgery Cluster, National University Health System, 1E Kent Ridge Road, 119228 Singapore

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Why it is important for an orthopaedic surgeon to know about imaging modalities in peri-prosthetic assessment Imaging is one essential part in the work-up of patients with total joint replacements. Although the actual scans are not done by the

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Gerhard M. Hobusch Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Kevin Döring Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Rickard Brånemark Gothenburg University, Gothenburg, Sweden
Biomechatronics Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Reinhard Windhager Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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success depends on thoughtful patient selection. 10 In parallel, surgical improvements, new prosthetic solutions and personal demands for higher activity levels accompanied with modern measurement instruments such as gait analysis and patient

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Donald J. Davidson Research Department of Orthopaedics and Musculoskeletal Sciences, University College London, London, UK
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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David Spratt Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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Alexander D. Liddle Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
MSK Lab, Imperial College London, London, UK

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Introduction Prosthetic joint infection (PJI) is one of the most feared complications of arthroplasty surgery due to its resistance to therapy with existing antibiotics. 1 It is a major cause of failure in arthroplasty, being the leading

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Yangqi Xu Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia

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Tony B Huang Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia

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Michael A Schuetz Jamieson Trauma Institute, Metro North Hospital and Health Service, Queensland Health, Brisbane, Queensland, Australia
Department of Orthopaedic Surgery, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia
Queensland University of Technology (QUT), Brisbane, Queensland, Australia

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Peter F M Choong Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia
Department of Orthopaedics, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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the ICARAUS group
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Introduction Prosthetic joint infection (PJI) is one of the most devastating post-surgical complications for a patient undergoing a total joint arthroplasty (TJA). As one of the leading causes of joint replacement failure, PJI causes implant

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Pablo A. Slullitel Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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José I. Oñativia Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Martin A. Buttaro Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Marisa L. Sánchez Infectology Department, Italian Hospital of Buenos Aires, Argentina

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Fernando Comba Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Gerardo Zanotti Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Francisco Piccaluga Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Introduction Being the third most common cause of revision surgery following primary total hip arthroplasty (THA), peri-prosthetic joint infection (PJI) constitutes one of the most undesired complications, with a prevalence of 0.3% to 2

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Tommaso Bonanzinga Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Matteo Carlo Ferrari Humanitas Clinical and Research Center, Milan, Italy

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Piergiuseppe Tanzi IRCCS Istituto Ortopedico Rizzoli; Università di Bologna, Dipartimento Scienze Biomediche e Neuromotorie, Bologna, Italy

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Filippo Vandenbulcke Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Akos Zahar Helios ENDO-Klinik, Hamburg, Germany

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Maurilio Marcacci Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Introduction Prosthetic joint infections (PJI) occur in 0.7% to 2.4% of patients and are responsible for 15% of failed total hip arthroplasties and 25% of revision total knee arthroplasties. 1 , 2 Almost any microorganism can cause PJI

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J R W Crutsen Department of Orthopaedic Surgery, VieCuri Medical Center, Venlo, the Netherlands

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M C Koper Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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J Jelsma Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands

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M Heymans Zuyderland Academy, Centre of Knowledge and Information (KIC), Zuyderland Medical Centre, Sittard-Geleen, the Netherlands

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I C Heyligers Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Health Professions Education (SHE), Maastricht University, Maastricht, the Netherlands

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B Grimm Luxembourg Institute Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg

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N M C Mathijssen Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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M G M Schotanus Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands

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debris (ARMD) ( 1 , 2 , 3 , 4 ). There is also an increasing number of case reports describing systemic reactions in relation to elevated blood cobalt concentrations known as prosthetic hip-associated cobalt toxicity (PHACT) ( 5 , 6 ). Increased

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