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Maria Beatriz Quaresma Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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José Portela Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Joaquim Soares do Brito Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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two of those patients (50%) moderate-to-severe osteoarthritis was identified. 12 , 14 Concerning arthritic progression from baseline, Colman et al identified a global rate of 15% – open synovectomy (0%) versus open-plus-arthroscopic synovectomy

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.5.200005
Volume/Issue:
Volume 5: Issue 6
Open access
Catalin Cirstoiu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Cretu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Sergiu Iordache Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Mihnea Popa Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Serban Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Adrian Cursaru Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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low life expectancy or if the region has already been irradiated. Radiation therapy begins immediately after surgery, and the radiated area should cover the entire implant; its purpose is to reduce pain, slow progression, or treat any remaining tumor

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-21-0119
Volume/Issue:
Volume 7: Issue 3
Open access
Irina-Anca Eremia Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Mihnea Popa Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Adela Iancu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Silvia Nica Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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the amount of time that a patient with RCC remains free from disease progression. This underscores the importance of angiogenesis in the pathological progression of RCC. In addition, the revolutionary implementation of immune checkpoint inhibitors

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0178
Volume/Issue:
Volume 9: Issue 6
Open access
Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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) decrease, progression of the disease is absent on radiographs and other imaging techniques, and reactive ossification appears mostly on the periphery of the lesion. This treatment is useful for downstaging a GCTB otherwise requiring mutilation surgery

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0138
Volume/Issue:
Volume 8: Issue 12
Open access
Julie J. Willeumier Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Yvette M. van der Linden Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Michiel A.J. van de Sande Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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P.D. Sander Dijkstra Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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as prophylaxis for tumour progression and implant failure. 23 However, this is not evidence-based and further prospective research should be performed before statements can be made concerning the effectiveness of adjuvant radiotherapy for all

Article Type:
Research Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.1.000008
Volume/Issue:
Volume 1: Issue 5
Open access
Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Joanna Szkandera Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Graz, Austria

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Dimosthenis Andreou Division of Orthopaedic Oncology and Sarcoma Surgery, Helios Klinikum Bad Saarow, Sarcoma Center Berlin-Brandenburg, Berlin, Germany

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Emanuela Palmerini Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy

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Marko Bergovec Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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mammalian target of rapamycin (mTOR) inhibitor ridaforolimus. 21 , 22 In particular, a progression free survival (PFS) of 3.5 to 3.9 months in patients with advanced sarcoma (both bone and soft tissue) was demonstrated for ridaforolimus, with manageable

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.5.200069
Volume/Issue:
Volume 5: Issue 11
Open access
Olga Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Ioannis Zafeiris First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Dimitra Melissaridou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
Co-senior authors

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reported that most cases of progression occurred in patients with multiple tumors. 67 Most cases of SPECS are low to intermediate grade, although tumours of higher grade are also possible. The tumour is far more common after maturity, usually 25 to 45

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.6.210064
Volume/Issue:
Volume 6: Issue 10
Open access
Miklós Szendrői Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Imre Antal Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Attila Szendrői Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Áron Lazáry National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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Péter Pál Varga National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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explained by our finding that when comparing the Fuhrman grade of the initial tumour, progression in the grade of metastases was found in 40%, downgrading in 30% and the same grade in 30%. This explains that the final outcome for the patient depends more on

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.2.170006
Volume/Issue:
Volume 2: Issue 9
Open access
Serkan Bayram Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Salduz Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Müçteba Yıldırım Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Korhan Özkan Department of Orthopedics and Traumatology, Istanbul Medeniyet University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Levent Eralp Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Harzem Özger Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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) reported that age did not affect the progression to knee osteoarthritis. Gender: Seven of the 61 patients in the 11 studies who developed osteoarthritis were male, and four were female. According to the results obtained from the random effects model with

Article Type:
Systematic Review
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0189
Volume/Issue:
Volume 9: Issue 3
Open access
Chengxiang Li Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
University of Basel, Basel, Switzerland

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Fatime Krasniqi Department of Oncology, University Hospital Basel, Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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Ricardo Donners The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Department of Radiology, University Hospital Basel, Basel, Switzerland

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Christoph Kettelhack The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Clarunis, University Digestive Health Care Center, St. Clara Hospital and University Hospital Basel, Switzerland

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Andreas H Krieg Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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. SSs presented a better response to chemotherapy (no particular regimen seemed superior, though ifosfamide did seem to be more active), a longer progression-free survival (PFS) (6.3 months vs 3.7 months), and a longer OS period (15.0 vs 11.7 months

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0193
Volume/Issue:
Volume 9: Issue 3
Open access