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History Arthroplasty became popular in the second half of the 20th century and has developed since then into one of the most successful fields in orthopaedics ( 1 ). This development was not free from problems and failures. The reduction of
School of Health Sciences, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Region, Larissa, Hellenic Republic
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Department of Traumatology and Orthopedics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
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Trauma, Emergency Surgery and Orthopaedics, Reconstructive Orthopaedics, Karolinska University Hospital, Stockholm, Sweden
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, 6 , 7 , 8 , 9 ). Soon, various problems with a substantial impact on the working environment and staff safety appeared related to the availability, use, rationing, modification, compliance and recycling of PPE ( 7 , 10 , 11 , 12 ). Later, it
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Introduction The basic concept of modern medicine is that treatment is based upon accurate diagnosis. In musculoskeletal problems and abnormalities, the diagnosis is frequently based upon pathological examination of a specimen taken from the
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK
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and solutions for healthcare problems. The positive impact of registries on healthcare outcomes and healthcare processes has been demonstrated. 2 Clinical registries are an essential part of the learning healthcare system. 3 They collect pre
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problems. Postoperative rehabilitation should begin soon after surgery, with attention paid to treatment of haemostasis and pain. Surgery in patients with inhibitor requires even more careful preparation. 2 Bleeds within the joints The vast
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with painful chest motion and are often managed with respiratory physiotherapy and rarely require intervention (i.e. chest tube) ( 19 ). Therefore, an effective analgesia strategy in STA is necessary. Respiratory problems may also be exacerbated by the
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antibiotic-resistant bacteria, the problem of ODRI is set to continue to pose a challenge for practising clinicians in the coming decades. The clinical and microbiological challenges of modern device-related infections The most prevalent species in
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National Joint Replacement for England, Wales, Northern Ireland, Isle of Man and the States of Guernsey (NJR)
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rates of revision for specific prostheses. Revisions are generally defined in joint registries as a removal or exchange of a prosthesis or part thereof and provide an unambiguous record of a problem with the joint replacement. There are many factors that
Université Claude Bernard Lyon 1, Villeurbanne, France
Centre de Références des IOA Complexes de Lyon, CRIOAc Lyon, Lyon, France
StaPath team, Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France
Education and Clinical Officer of the ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA)
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Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium
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Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium
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). Although the biofilm is a well-known problem in MSIs, the increasing incidence of antimicrobial resistance (AMR) is potentially even more worrisome. The most frequently isolated pathogen in MSI is Staphylococcus aureus (30–42%) ( 8 ). Despite a decrease
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Long bone non-unions represent a serious clinical and socioeconomical problem due to the prolonged episodes, frequent sequelae, and variable treatment effectiveness.
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Bone grafts, classically involving the autologous iliac crest graft as the ‘gold standard’ bone graft, enhance bone regeneration and fracture healing incorporating osteoconductive and/or osteoinductive/osteogenic capacity to the non-union under treatment.
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Structural alternatives to autologous bone grafts include allografts and bone substitutes, expanding the available stock but loosing biological properties associated with cells in the graft.
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Biological alternatives to autologous bone grafts include bone marrow concentration from iliac crest aspiration, bone marrow aspiration from reaming of the diaphyseal medullary canal in the long bones, and isolated, expanded mesenchymal stem cells under investigation.
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When the combination with natural and synthetic bone substitutes allows for larger volumes of structural grafts, the enhancement of the biological regenerative properties through the incorporation of cells and their secretoma permits to foresee new bone grafting solutions and techniques.
