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Introduction The main pathological changes of osteoarthritis (OA) are related to cartilage degeneration, subchondral bone thickening, synovitis, and structural lesions of the joint capsules, ligaments, and associated muscles ( 1 , 2 ). The
Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK
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meniscus is an intra-articular structure composed primarily of type 1 collagen. Its main functions are shock absorption, proprioception, lubrication and joint stability. 30 It is vulnerable to repetitive injury which can predispose to osteoarthritis
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Introduction Anterior cruciate ligament (ACL) injury represents a well-recognized risk factor for the future development of knee osteoarthritis (OA) ( 1 ) as instability is a leading cause of cartilage and meniscal damage with a growing
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menisci due to senescence, trauma or surgery eventually leads to osteoarthritis of the knee joint, independent of meniscus morphology. 10 - 16 Fig. 1. Arthroscopic view illustrating meniscal vascularity. Note the bleeding from the peripheral part
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functional rehabilitation. 9 Failure of non-surgical treatment can result in debilitating, persistent medial instability, secondary anterior cruciate ligament (ACL) dysfunction, weakness, and osteoarthritis. 10 In a review by Varelas et al, the most
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structures of the meniscus are determined by its functions. Alteration of its morphology could lead to early degenerative osteoarthritis. 11 The medial meniscus is C-shaped and slightly smaller than the lateral meniscus. 12 The lateral meniscus is
Ripoll y De Prado Sports Clinic, Murcia-Madrid, FIFA Medical Centre of Excellence, Madrid, Spain
International Centre of Sports Traumatology of the Ave, Vila do Conde, Portugal
3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clínica do Dragão, Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal
Orthopedic Department, University of Minho, Braga, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Orthopaedic Department, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal
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, considering the cartilage condition and ligament status and function. 45 The first description of meniscus allograft transplantation (MAT) was in the 1970s, in patients with post-traumatic osteoarthritis secondary to fractures of the tibial plateau
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stresses in the adjacent intact cartilage. 7 – 9 If left untreated, progressive cartilage degeneration and ultimately ‘early-onset’ osteoarthritis may occur. 10 The management of chondral defects is challenging. Numerous surgical techniques have
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knee osteoarthritis (OA) increases to between approximately 15% and 20% after an ACL tear, which represents a ten-fold increase. 6 It is suggested that more than 50% of patients that sustain an ACL injury will develop symptomatic OA in the
Clínica Alemana-Universidad del Desarrollo, Santiago, Chile
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Hospital Padre Hurtado, Santiago, Chile
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3Bs Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal; ICVS/3Bs–PT Government Associate Laboratory, Portugal
Orthopaedics Department of Minho University, Portugal
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defects, instability or malalignment should be amenable to surgical correction. On the other hand, classical contraindications are: advanced osteoarthritis, obesity, skeletal immaturity, inflammatory arthritis, previous septic arthritis, and synovial