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Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Sandra Bösmüller AUVA Trauma Centre Vienna Meidling, Vienna, Austria

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Paul Puchwein Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Martin Ornig Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Franz-Josef Seibert Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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open reduction and internal fixation (ORIF) or minimally invasive plate osteosynthesis (MIPO), and retrograde and antegrade intramedullary nailing (IM) ( 6 , 8 , 9 ). Complications of both conservative and operative treatment approaches are non-union

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Andreas Frodl Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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Johannes Hauss Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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Andreas Fuchs Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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Markus Siegel Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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Hagen Schmal Department of Orthopedic Surgery, University Hospital Odense, Odense, Denmark

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Jan Kühle Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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of non-union, delayed union and wound infections there is no consensus concerning the treatment of distal femoral fractures. We carried out a meta-analysis to validate our hypothesis, that RIMN is superior to plate fixation for lowering the risk of

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Luke Turley Department of Orthopaedics, Midland Regional Hospital Tullamore, Tullamore, Ireland

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Ian Barry Department of Plastic Surgery, Royal Perth Hospital, Perth, Western Australia, Australia

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Eoin Sheehan Department of Orthopaedics, Midland Regional Hospital Tullamore, Tullamore, Ireland

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tibial shaft fractures are associated with high rates of complications including malunion, non-union and infection ( 5 , 6 ). The severity of the soft tissue injury associated with open fractures has been considered significant for many years. In 1976

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Karl Stoffel Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland

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Christoph Sommer Department of Surgery, Kantonsspital Graubuenden, Chur, Switzerland

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Mark Lee Department of Orthopaedic Surgery, UC Davis Medical Center, Sacramento, California, USA

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Tracy Y Zhu AO Innovation Translation Center, AO Foundation, Davos, Switzerland

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Karsten Schwieger AO Innovation Translation Center, AO Foundation, Davos, Switzerland

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Christopher Finkemeier Sutter Roseville Medical Center, Roseville, California, USA

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over 60 years old ( 3 ). Retrograde intramedullary nail (rIMN) and lateral locking compression plate (LCP) are common surgical treatments for distal femoral fractures. Healing difficulties following locking plate are not uncommon. Rates of non-union are

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Maartje Michielsen Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium

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Annemieke Van Haver Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium

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Matthias Vanhees Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium
Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium

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Roger van Riet Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium
Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium

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Frederik Verstreken Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium
Department of Orthopaedic Surgery, University Hospital Antwerp, Antwerp, Belgium

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select the most appropriate implants for internal fixation. 8 , 10 – 12 Based on this, patient-specific bone models can be 3D printed, sterilized and used in the operating room. Non-union and malunion are the most common serious complications of

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, ‘Infanta Elena’ University Hospital, Valdemoro, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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treatment and complications . Rev Med Suisse 2011 ; 7 : 2482 , 2484 – 2488 . 6. Andrzejowski P Giannoudis PV . The ‘diamond concept’ for long bone non-union management . J Orthop Traumatol 2019 ; 20 : 21 . 7

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Abdel Rahim Elniel Leeds Teaching Hospitals Trust, UK

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Peter V. Giannoudis Academic Department of Trauma and Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK; NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, UK

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. Risk factors for long bone fracture non-union: a stratification approach based on the level of the existing scientific evidence . Injury 2015 ; 46 ( suppl 8 ): S8 - S19 . 69. Tay W-H de Steiger R Richardson M Gruen

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Guo-xu Zhang Guangzhou University of Chinese Medicine, Guangzhou, China

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Ji Li Guangzhou University of Chinese Medicine, Guangzhou, China

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Qi-jun Xie Guangzhou University of Chinese Medicine, Guangzhou, China

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Mei-ren Zhang Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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Kui Zhao Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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Hai-yun Chen Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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complications was defined as incorporating all complications reported in the literature ( 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ), including plate fracture, malunion, delayed union, nonunion, incision infection, etc. The criteria for non-union

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Andrew J Harrison Bioventus International, Taurusavenue, Hoofddorp, Netherlands

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Michael R Redler Connecticut Orthopaedics, Department of Orthopaedics, University of Virginia, Frank H. Netter School of Medicine, Quinnipiac University, USA

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David M Taylor Leeds General Infirmary, Leeds, UK

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Ansar Mahmood Department Trauma & Orthopaedic Surgery, Queen Elizabeth Hospital, Birmingham, UK

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John T Jones Statistician - Raleigh, NC

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Yukihiro Arai Department of Orthopaedic Surgery, Teikyo University School of Medicine

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Yoshinobu Watanabe Department of Orthopaedic Surgery, Teikyo University School of Medicine

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Introduction Fracture incidence is common, with over one million fractures occurring each year in the United Kingdom alone ( 1 ). However, failure to heal a fracture is rare, with Zura et al. ( 2 ) reporting a non-union rate of just 4.9% in

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Hua Luo Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Graduate Student Training Base, Jinzhou Medical University, Jinzhou, China

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Liang Ding Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Haijun Xiao Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Ming Wu Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Feng Xue Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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of 18 years with nonunion or delayed union after IMN in femoral shaft fracture; (2) both exchange nailing (EN) and augmentative plating (AP) were adopted; and (3) both randomized and non-randomized studies were included. Exclusion criteria were: (1

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