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Miklós Szendrői Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Imre Antal Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Attila Szendrői Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Áron Lazáry National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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Péter Pál Varga National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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associated with consequent pathological fracture and neurological impairment which significantly worsen the patient’s quality of life as well as survival. Early recognition of unstable lesions is crucial in the treatment choice, but the evaluation of

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, 417 Veterans Hospital (NIMTS), Athens, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Ioannis Papanastasiou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Thomas Sarlikiotis First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Aggelos Kaspiris Laboratory of Molecular Pharmacology/ Sector for Bone Research, School of Health Sciences, University of Patras, Patras, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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to months before the diagnosis. Neurologic symptoms may also develop secondary to pressure or tenting of the nerve structures in the elbow area. Radiographically, ABC usually presents as a metaphyseal eccentric lesion, that may elevate the periosteum

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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, although the clinical presentation of the most frequent lesions might be straightforward, it can often be difficult to differentiate benign and reactive lesions from malignant and aggressive ones on purely clinical grounds. Thus, it is important for the

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Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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underlining the ineffectiveness of denosumab on the tumourous stromal cells ( 1 ). Following the successful use of denosumab in the treatment of osteoporosis and metastatic bone lesions ( 2 , 3 ), it has been approved by FDA in 2013 and later on by the

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Maria Beatriz Quaresma Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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José Portela Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Joaquim Soares do Brito Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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behaviours, as well as the variety of joints involved, is difficult to establish an absolute standard for treatment. 8 The current consensus for treating a diffuse tenosynovial giant-cell tumour of the knee is surgical resection of the lesional tissue

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Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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and diagnosis Early diagnosis is key to managing local recurrence, and imaging techniques have been suggested as a way to identify high-risk patients at an earlier stage. Confirming the diagnosis of a clinically suspicious lesion is the main goal of

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Daniel Kotrych Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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Andrzej Bohatyrewicz Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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. Spinopelvic reconstruction should be considered, in relation to expected neurologic loss and functional instability ( Fig. 1 ), following a total or high sacrectomy or sacroiliac joint removal. Figure 1 Types of sacral bone resection: type 1 – low

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