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associated with consequent pathological fracture and neurological impairment which significantly worsen the patient’s quality of life as well as survival. Early recognition of unstable lesions is crucial in the treatment choice, but the evaluation of
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to months before the diagnosis. Neurologic symptoms may also develop secondary to pressure or tenting of the nerve structures in the elbow area. Radiographically, ABC usually presents as a metaphyseal eccentric lesion, that may elevate the periosteum
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, although the clinical presentation of the most frequent lesions might be straightforward, it can often be difficult to differentiate benign and reactive lesions from malignant and aggressive ones on purely clinical grounds. Thus, it is important for the
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underlining the ineffectiveness of denosumab on the tumourous stromal cells ( 1 ). Following the successful use of denosumab in the treatment of osteoporosis and metastatic bone lesions ( 2 , 3 ), it has been approved by FDA in 2013 and later on by the
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behaviours, as well as the variety of joints involved, is difficult to establish an absolute standard for treatment. 8 The current consensus for treating a diffuse tenosynovial giant-cell tumour of the knee is surgical resection of the lesional tissue
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and diagnosis Early diagnosis is key to managing local recurrence, and imaging techniques have been suggested as a way to identify high-risk patients at an earlier stage. Confirming the diagnosis of a clinically suspicious lesion is the main goal of
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. Spinopelvic reconstruction should be considered, in relation to expected neurologic loss and functional instability ( Fig. 1 ), following a total or high sacrectomy or sacroiliac joint removal. Figure 1 Types of sacral bone resection: type 1 – low