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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, 417 Veterans Hospital (NIMTS), Athens, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Ioannis Papanastasiou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Thomas Sarlikiotis First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Aggelos Kaspiris Laboratory of Molecular Pharmacology/ Sector for Bone Research, School of Health Sciences, University of Patras, Patras, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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radiofrequency thermal ablation (RFA) or arthroscopic excision. 8 Moreover, the management and prognosis of patients with malignant tumours, such as Ewing sarcoma and osteosarcoma, have improved thanks to the adjuvant chemotherapeutic protocols and improved

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Chengxiang Li Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
University of Basel, Basel, Switzerland

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Fatime Krasniqi Department of Oncology, University Hospital Basel, Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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Ricardo Donners The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Department of Radiology, University Hospital Basel, Basel, Switzerland

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Christoph Kettelhack The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Clarunis, University Digestive Health Care Center, St. Clara Hospital and University Hospital Basel, Switzerland

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Andreas H Krieg Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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signal intensity on fluid-sensitive MRI sequences suggest necrosis and a favorable response, while a reduction in size can be present. Overall, larger SS usually show features typical for a malignant soft tissue tumor with potentially suggestive

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Introduction Soft tissue tumours around the elbow are rare, with an incidence of around 3.8% of all soft tissue tumours. 1 Benign soft tissue tumours occur approximately 10 times more frequently than malignant ones. 2 Nevertheless

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E. Mascard Necker University Hospital, 75015 Paris, France.

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N. Gaspar Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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L. Brugières Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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C. Glorion Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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S. Pannier Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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A. Gomez-Brouchet Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France

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Introduction Benign tumours and tumour-like lesion of the foot and ankle are not uncommon but malignant tumours and especially malignant bone tumours of the foot are rare. Most of the foot tumours are benign: usually synovial cysts (30% of

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Olga Savvidou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Dimitra Melissaridou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
Co-senior authors

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MO in comparison to other bone or soft tissue malignant tumours that emerge in the differential diagnosis of a rapid-growing muscular mass. Awareness that MO may simulate bone and soft tissue tumours can help orthopaedic surgeons in a prompt diagnosis

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Marta Salom Department of Pediatric Orthopedic, La Fe University and Polytechnique Hospital, Valencia, Spain

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Inês Balacó Department of Pediatric Orthopedic, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal

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they are benign or malignant. For this reason, it is very important to know what are the main signs that help in the differential diagnosis (DD). The correct diagnosis can be provided in >80% of cases with careful consideration of the history of the

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Robert Grimer The Royal Orthopaedic Hospital, Birmingham, UK

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Michael Parry The Royal Orthopaedic Hospital, Birmingham, UK

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Steven James The Royal Orthopaedic Hospital, Birmingham, UK

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maybe distressed when the pathologist reports that the lesion which they thought was benign, is in fact malignant! 2 Almost always the surgeon will have ‘shelled out’ the lump and will usually confidently say that they ‘have got it all out’. In the

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James Plant Royal National Orthopaedic Hospital, Stanmore, UK

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Stephen Cannon Royal National Orthopaedic Hospital, Stanmore, UK

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necessary to maintain a high index of suspicion for tumours in order to not miss the diagnosis when it arises. Sarcomas are malignant tumours of mesodermal origin. They are frequently aggressive, and more prevalent in a younger patient group compared to

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Daniel Kotrych Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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Andrzej Bohatyrewicz Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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primary malignant bone tumors without compromising the oncological outcome ( 7 , 8 , 9 ). Prosthetic reconstructions after primary bone tumor removal can be divided into two groups based on (i) availability of modular implants or (ii) custom implants for

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Olga Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Ioannis Zafeiris First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Dimitra Melissaridou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
Co-senior authors

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and cartilage. 1 – 4 Osseous surface bone tumours include benign tumours such as osteoma, osteoid osteoma and osteoblastoma, and the malignant category of surface osteosarcomas (parosteal, periosteal and high-grade osteosarcoma), while the

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