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Julie J. Willeumier Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Yvette M. van der Linden Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Michiel A.J. van de Sande Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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P.D. Sander Dijkstra Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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, size, site and lesion aspect. 11 , 12 However, because these factors are based on retrospective research, their predictive value is low. 10 Based on prospective research, we advise the use of the axial cortical involvement of > 30 mm and a

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Ajay Puri Department of Surgery, Tata Memorial Hospital, HBNI, Mumbai

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tumour cells, whether chondroid or osteoid can help differentiate a chondrosarcoma from an osteosarcoma. Grading of a chondrosarcoma is based on cellularity, nuclear size, degree of nuclear staining (hyperchromasia) and presence of mitotic figures. 16

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, 417 Veterans Hospital (NIMTS), Athens, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Ioannis Papanastasiou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Thomas Sarlikiotis First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Aggelos Kaspiris Laboratory of Molecular Pharmacology/ Sector for Bone Research, School of Health Sciences, University of Patras, Patras, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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-mechanical rest pain, soft tissue swelling, change in size of the mass, fever, night sweats and chills, which would warrant a higher level of suspicion for malignancy. 4 Diagnostic imaging is an important component of the workup of a patient with a

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Maria Anna Smolle Medical University of Graz, Austria

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Dimosthenis Andreou Münster University Hospital, Germany

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Per-Ulf Tunn Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Germany

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Joanna Szkandera Medical University of Graz, Austria

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Bernadette Liegl-Atzwanger Medical University of Graz, Austria

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Andreas Leithner Medical University of Graz, Austria

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lower limbs, followed by the upper limbs and trunk. 8 Further common locations include the head/neck region and retroperitoneal space. 9 As these STSs are usually seen by Ear-Nose-Throat physicians and Gastrointestinal surgeons, they will not

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Olga Savvidou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Dimitra Melissaridou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
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Panayiotis J. Papagelopoulos First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
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extra-skeletal soft tissues of the upper and lower extremities, most commonly in the brachialis, deltoid, quadriceps and adductors, although atypical locations including intercostal or abdominal muscles, head, hands, feet and neck have been reported. 9

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Daniel Kotrych Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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Andrzej Bohatyrewicz Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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pelvic acetabular resections when a cup with modular stem cannot be used due to the small size of the residual ilium. For tumors of the sacrum, the resection procedure must be prepared in terms of oncological adequacy, but also considering the possible

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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, 60 tumour located in the extremities and a large tumour size. 61 Regarding positive margins though, they do not lead inevitably to LR, since many tumours recur after wide resection whereas after incomplete resection disease may remain stable

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