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Joaquim Soares do Brito Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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André Spranger Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Paulo Almeida Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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José Portela Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Irene Barrientos-Ruiz Orthopedics Department, University Hospital of La Paz, Madrid

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Introduction Giant cell tumour (GCT) of bone is a relatively rare, locally aggressive benign neoplasm associated with a wide pathological spectrum, ranging from latent benign to highly recurrent and, occasionally, malignant metastatic

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.6.200154
Volume/Issue:
Volume 6: Issue 8
Open access
Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Introduction Denosumab is a fully humanised monoclonal antibody of the RANK ligand (nuclear factor kappa B ligand) which inhibits the RANK–RANKL interaction. The mononuclear stromal cells of giant cell tumour of bone (GCTB) overexpress RANKL

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0138
Volume/Issue:
Volume 8: Issue 12
Open access
Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, 417 Veterans Hospital (NIMTS), Athens, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Ioannis Papanastasiou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Thomas Sarlikiotis First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Aggelos Kaspiris Laboratory of Molecular Pharmacology/ Sector for Bone Research, School of Health Sciences, University of Patras, Patras, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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the osteoid osteoma, the giant cell tumour, the aneurysmal bone cyst and the fibrous dysplasia. Ewing sarcoma, osteosarcoma and chondrosarcoma of the elbow are the most common malignant tumours, and occur more frequently in older patients with the

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.4.180086
Volume/Issue:
Volume 4: Issue 4
Open access
James Plant Royal National Orthopaedic Hospital, Stanmore, UK

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Stephen Cannon Royal National Orthopaedic Hospital, Stanmore, UK

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the location of the anomaly within that bone. The site of the lesion is sometimes pathognomonic. Giant cell tumour (a usually benign but locally aggressive disease) classically crosses the physis into the epiphysis and extends through the subchondral

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.1.000035
Volume/Issue:
Volume 1: Issue 6
Open access
Serkan Bayram Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Salduz Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Ahmet Müçteba Yıldırım Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Korhan Özkan Department of Orthopedics and Traumatology, Istanbul Medeniyet University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Levent Eralp Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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Harzem Özger Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey

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.05.008 ) 10 Gaston CL Bhumbra R Watanuki M Abudu AT Carter SR Jeys LM Tillman RM & Grimer RJ . Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone? Journal of Bone and Joint Surgery

Article Type:
Systematic Review
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0189
Volume/Issue:
Volume 9: Issue 3
Open access
Olga Savvidou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Dimitra Melissaridou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
Co-senior authors

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extend to skeletal muscle. (I) (H&EX100) Well-formed bone trabeculae, osteoid and plump fibroblasts in collagenized stroma. Cystic areas are noted at the lower left. (J) (H&EX200) Areas of multinucleated osteoclast-like giant cells adjacent to osteoid. (K

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.6.210002
Volume/Issue:
Volume 6: Issue 7
Open access
Maria Beatriz Quaresma Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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José Portela Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Joaquim Soares do Brito Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Introduction Tenosynovial giant-cell tumour (TGCT) has been previously known as a giant-cell tumour of the tendon sheath or pigmented villonodular synovitis (PVNS), and can also be called a xanthogranuloma, a benign synovioma, or a fibrous

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.5.200005
Volume/Issue:
Volume 5: Issue 6
Open access
Maria A. Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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Dimosthenis Andreou Department of General Orthopaedics and Tumour Orthopaedics, University Hospital Muenster, Germany

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Per-Ulf Tunn Tumour Orthopaedics, HELIOS Klinikum Berlin-Buch, Germany

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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allograft-prosthetic composite for proximal tibial bone sarcoma included (18 osteosarcomas, three Ewing sarcomas, one giant cell tumour) – mean follow-up of 6.5 years – mean implant survival of 68 months, with major complications including one infection, two

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.4.180081
Volume/Issue:
Volume 4: Issue 7
Open access
Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis) . J Bone Joint Surg Br 2012 ; 94 : 882 – 888 . 46. Inoue Y Ishida H Ueno H et al

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.4.190002
Volume/Issue:
Volume 4: Issue 12
Open access
Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Distal radius reconstruction after giant cell tumour resection using fibular autograft. Bone allografts can be used for intercalary defects reconstruction or as osteochondral allografts, but often with modest long-term functional results. Despite

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.4.180048
Volume/Issue:
Volume 4: Issue 5
Open access