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Frontiers in non-union research

Enrique Gómez-Barrena

Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz

Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset

Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing.
Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products.
Basic science and research on non-union treatments is needed to compile preclinical data on new treatments.
Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment.
Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products.

Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062