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Djandan Tadum Arthur Vithran Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Anko Elijah Essien Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Masoud Rahmati Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran

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Michael Opoku Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Dong Keon Yon Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea

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Guillermo F López Sánchez Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain

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Ai Koyanagi Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

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Lee Smith Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK

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Jae Il Shin Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

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Wenfeng Xiao Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shuguang Liu Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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Yusheng Li Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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fragility fractures. Their findings support our conclusions, further emphasizing the importance of these drugs in the clinical landscape. Lastly, Hong et al. ( 76 ) conducted a meta-analysis comparing the efficacy of abaloparatide and teriparatide, with

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Dimitrios A. Flevas First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Evanthia Mitsiokapa First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis Koulouvaris First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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older people . Edinburgh : SIGN , 2009 . http://www.sign.ac.uk/pdf/sign111.pdf Last accessed April 5 , 2018 . 75. British Orthopaedic Association . The care of patients with fragility fracture . http://www.fractures

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Jean-Charles Aurégan Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.
Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.
Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Catherine Bosser Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Morad Bensidhoum Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Thierry Bégué Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.

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Thierry Hoc Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Introduction Osteoporosis is a systemic condition associating a reduction of bone mass and a modification of bone micro-architecture. It leads to a mechanical fragility and a higher risk of fracture. 1 The exact pathophysiology of

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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haemophilic arthropathy, muscle wasting, and osteoporosis render the bone more fragile and prone to fracture. 48 The goal of modern fracture treatment must be to obtain an optimal outcome with the patient’s return to full activity as soon as possible

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Tristan Ferry Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
Université Claude Bernard Lyon 1, Villeurbanne, France
Centre de Références des IOA Complexes de Lyon, CRIOAc Lyon, Lyon, France
StaPath team, Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France
Education and Clinical Officer of the ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA)

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Jolien Onsea Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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Tiphaine Roussel-Gaillard Institut des Agents Infectieux, Centre de Biologie et de Pathologie du Nord, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Cécile Batailler Service de Chirurgie Orthopédique et de Médecine du Sport, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Thomas Fintan Moriarty AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, Switzerland

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Willem-Jan Metsemakers Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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incidence of PJI in most centres ranges between 0.5% and 2% ( 3 , 5 ), the incidence for FRI varies widely, from 1% to 30%, depending to a large degree on injury severity ( 6 ). Given the ageing population, with a growing number of fragility fractures, and

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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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destruction of bone microstructure, resulting in increased bone fragility and fracture susceptibility ( 76 ). OP is divided into two categories: primary OP and secondary OP. Primary OP mainly includes senile OP and postmenopausal OP (PMOP). Many diseases may

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İlker Eren Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Cemil Cihad Gedik Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Uğur Kılıç Koç University, School of Medicine, Istanbul, Turkey

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Berk Abay Koç University, School of Medicine, Istanbul, Turkey

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Olgar Birsel Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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Mehmet Demirhan Koç University, School of Medicine, Department of Orthopaedics and Traumatology, Istanbul, Turkey

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to facilitate union. A ball tip high-speed burr is used to prepare the ventral surface of scapula and dorsal surfaces of selected adjacent ribs. Note that both scapula and ribs are fragile with thin cortices. Therefore, creating a rough surface

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Congcong He Department of Psychology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yong Zhao Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai, China

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Guangyong Yang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hainan Hong Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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great damage to joints, erode joint cartilage, increase the fragility of soft tissues and ligaments around the joints, and deteriorate soft tissue conditions ( 6 ). Acute SA is defined by those patients that present with altered clinical (fever

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