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Maik Sliepen Institut für Experimentelle Muskuloskelettale Medizin (IEMM), Universitätsklinikum Münster (UKM), Westfälische Wilhelms-Universität Münster (WWU), Germany

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Matthijs Lipperts AHORSE, Department of Orthopaedics, Zuyderland Medical Centre, The Netherlands

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Marianne Tjur Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark

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Inger Mechlenburg Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark
Centre of Research in Rehabilitation (CORIR), Department of Clinical Medicine, Aarhus University Hospital and Aarhus University, Denmark

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defined as any ‘bodily movement produced by skeletal muscles that results in energy expenditure’, 6 and can thus vary from household activities to strenuous exercise. Whether PA beneficially affects the health of an individual seems to depend on the

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Francesco Smeraglia Department of Public Health, Division of Orthopaedic Surgery, ‘Federico II’ University, Naples, Italy

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Federico Tamborini Department of Biotechnology and Life Sciences, Division of Plastic and Reconstructive Surgery, University of Insubria, Varese, Italy

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Leonardo Garutti Department of Biotechnology and Life Sciences, Division of Plastic and Reconstructive Surgery, University of Insubria, Varese, Italy

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Andrea Minini Department of Biotechnology and Life Sciences, Division of Plastic and Reconstructive Surgery, University of Insubria, Varese, Italy

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Morena A. Basso Department of Public Health, Division of Orthopaedic Surgery, ‘Federico II’ University, Naples, Italy

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Mario Cherubino Department of Biotechnology and Life Sciences, Division of Plastic and Reconstructive Surgery, University of Insubria, Varese, Italy

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volume during exercise. 1 CECS of the lower limb is well reported; 2 whereas CECS of the forearm is a rare condition in the general population, but can be observed in motorcycling racers, climbers, and rowers. 3 Clinically, the

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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methods to mechanically induce osteoblastic differentiation (e.g. extracorporeal shock wave therapy or low intensity pulsed ultrasound), and growth factors to stimulate cell growth and differentiation (most studies focussing on bone morphogenetic proteins

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