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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Han Zhang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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’ condition TXA administration Outcomes He et al. ( 11 ) Low Degenerative conditions 10 mg/kg i.v. before skin incision + 6–8 mg/kg/h i.v. during the surgery IBL, total postoperative drainage, time for drainage removal, hospital stay

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xuelei Zhang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chengxin Xie Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Department of Endocrinology, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Luxia Wu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Guoping Cai Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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ultimately achieves the purpose of reducing the TBL. The study by Arun-Kumar et al. ( 27 ) included four groups: preoperative intravenous TXA, preoperative local infiltration of TXA in the paravertebral muscles at the incision, tTXA before closing the

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chaojun Shen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Tongyou Qu Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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Lin Chen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yue Sun Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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only be used in the subcutaneous and muscle around the incision. What happens if TXA enters the spinal canal or the cerebrospinal fluid? Recently, we used TXA local combined with intravenous administration in a patient with lumbar spine surgery for

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Alpaslan Senkoylu Gazi University, Department of Orthopaedics and Traumatology, Ankara, Turkey

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Rolf B. Riise Oslo University Hospital, Orthopaedic Clinic, Oslo, Norway

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Emre Acaroglu Ankara Spine Centre, Ankara, Turkey

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Ilkka Helenius University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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curve of Cobb > 25 degrees and progressive Cobb angle, or an RVAD (rib-vertebral angle difference) of more than 20 degrees 8 rib phase 2, or a double curve, cast correction is recommended. With curves less than 60 degrees a full recovery of the

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Qiushi Bai Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Yuanyi Wang Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China

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Jiliang Zhai Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Jigong Wu Chinese People’s Liberation Army Strategic Support Force Characteristic Medical Center, Beijing, China

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Yan Zhang Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Yu Zhao Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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compression can be aggravated by neurological deficits caused by coexisting lesions, and the neurological response to single regional decompression is also lower in patients with TSS ( 57 ). Some studies used ‘double crush syndrome’ to explain the severity of

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Miguel Relvas-Silva Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal

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Bernardo Sousa Pinto MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine, University of Porto, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal

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António Sousa Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal

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Miguel Loureiro Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Hospital das Forças Armadas, Porto, Portugal

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André Rodrigues Pinho Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

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Pedro Pereira NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal

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specified) and Kang, 2021 ( 25 ) (double-level surgery); *Values are mean ± s.d. ; † Some concerns. –, missing data; Bi, biportal; Endo, endoscopic; IL, interlaminar; LIF, lumbar interbody fusion; MIS, minimally invasive surgery; NOS, cohort study

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