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Ioannis Gkiatas Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Anastasia Boptsi Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Dimitra Tserga Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Ioannis Gelalis Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Dimitrios Kosmas Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Emilios Pakos Orthopaedic Department, School of Medicine, University of Ioannina, Ioannina, Greece

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Note . GWAS, genome-wide association study. Genes related to DDH occurrence WISP3 gene WNT1-inducible-signaling pathway protein 3 (WISP3) as a member of the CCN family regulates cell growth and differentiation. WISP3 was reported to be

Article Type:
Review Article
Category:
Research
DOI:
https://doi.org/10.1302/2058-5241.4.190006
Volume/Issue:
Volume 4: Issue 10
Open access
Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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include decreased local osteogenesis, as concluded by Bajada et al, 27 who demonstrated increased levels of the Wnt signalling inhibitor, DKK1, secreted by cells in the vicinity of the non-union site. This Wnt pathway inhibition could limit BMP

Article Type:
Review Article
Category:
Research
DOI:
https://doi.org/10.1302/2058-5241.5.190062
Volume/Issue:
Volume 5: Issue 10
Open access