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Metagenomic next-generation sequencing in osteoarticular infections with a focus on pediatrics: current concepts and clinical applications

Marco Gupton

Marco Gupton MountainView Regional Medical Center, Orthopaedic Surgery Residency, Las Cruces, New Mexico, USA

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Jessica Burns

Jessica Burns Department of Orthopaedic Surgery, Phoenix Children’s Hospital, Phoenix, Arizona, USA

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. They state that mNGS did not alter management in the majority of cases and provided minimal diagnostic value with additional cost to conventional testing. Table 1 Comparison of PCR and mNGS. Diagnostic test Advantages Disadvantages

Article Type:: Review Article

Category:: Paediatrics

DOI:: https://doi.org/10.1530/EOR-22-0136

Volume/Issue:: Volume 8: Issue 4

Open access

How to distinguish a benign from a malignant tumour in children and when should a biopsy be done and by whom

Marta Salom

Marta Salom Department of Pediatric Orthopedic, La Fe University and Polytechnique Hospital, Valencia, Spain

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Inês Balacó

Inês Balacó Department of Pediatric Orthopedic, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal

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. What is the lesion doing to the bone? The majority of the bone tumours are osteolytic, but they can also be osteoblastic. The osteolysis in a bone tumour is performed by osteoclasts which are activated via the RANK ligand pathway ( 11 ). Lodwick