Tommaso Bonanzinga
Tommaso Bonanzinga
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Tommaso Bonanzinga in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Tommaso Bonanzinga in
Google Scholar
PubMed
Pietro Conte
Pietro Conte
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Pietro Conte in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Pietro Conte in
Google Scholar
PubMed
Giuseppe Anzillotti
Giuseppe Anzillotti
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Giuseppe Anzillotti in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Giuseppe Anzillotti in
Google Scholar
PubMed
Vincenzo Longobardi
Vincenzo Longobardi
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Vincenzo Longobardi in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Vincenzo Longobardi in
Google Scholar
PubMed
Elizaveta Kon
Elizaveta Kon
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
Maria Rescigno
Maria Rescigno
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maria Rescigno in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maria Rescigno in
Google Scholar
PubMed
Maurilio Marcacci
Maurilio Marcacci
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
different pathways ( 21 ). A great impulse in this quest was given by the introduction of next-generation sequencing (NGS). Indeed, NGS techniques and metagenomics can provide a view of the transcriptome of the host tissue as well as capture all microbial
Vikki Wylde
Vikki Wylde
Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, UK.
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
Search for other papers by Vikki Wylde in
Google Scholar
PubMed
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
Search for other papers by Vikki Wylde in
Google Scholar
PubMed
Andrew Beswick
Andrew Beswick
Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, UK.
Search for other papers by Andrew Beswick in
Google Scholar
PubMed
Search for other papers by Andrew Beswick in
Google Scholar
PubMed
Julie Bruce
Julie Bruce
Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, UK.
Search for other papers by Julie Bruce in
Google Scholar
PubMed
Search for other papers by Julie Bruce in
Google Scholar
PubMed
Ashley Blom
Ashley Blom
Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, UK.
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Search for other papers by Ashley Blom in
Google Scholar
PubMed
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Search for other papers by Ashley Blom in
Google Scholar
PubMed
Nicholas Howells
Nicholas Howells
North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Search for other papers by Nicholas Howells in
Google Scholar
PubMed
Search for other papers by Nicholas Howells in
Google Scholar
PubMed
Rachael Gooberman-Hill
Rachael Gooberman-Hill
Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, UK.
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
Search for other papers by Rachael Gooberman-Hill in
Google Scholar
PubMed
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, UK.
Search for other papers by Rachael Gooberman-Hill in
Google Scholar
PubMed
to assess these domains of pain separately. 20 , 56 Pain can also be categorized as nociceptive or neuropathic, where the former arises from activity in neural pathways secondary to tissue damage and the latter arises from a lesion or disease of
Richard Peter Almeida
Richard Peter Almeida
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
Search for other papers by Richard Peter Almeida in
Google Scholar
PubMed
Search for other papers by Richard Peter Almeida in
Google Scholar
PubMed
Lipalo Mokete
Lipalo Mokete
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
Search for other papers by Lipalo Mokete in
Google Scholar
PubMed
Search for other papers by Lipalo Mokete in
Google Scholar
PubMed
Nkhodiseni Sikhauli
Nkhodiseni Sikhauli
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
Search for other papers by Nkhodiseni Sikhauli in
Google Scholar
PubMed
Search for other papers by Nkhodiseni Sikhauli in
Google Scholar
PubMed
Allan Roy Sekeitto
Allan Roy Sekeitto
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
Search for other papers by Allan Roy Sekeitto in
Google Scholar
PubMed
Search for other papers by Allan Roy Sekeitto in
Google Scholar
PubMed
Jurek Pietrzak
Jurek Pietrzak
Arthroplasty Unit, Division of Orthopaedic Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa
Search for other papers by Jurek Pietrzak in
Google Scholar
PubMed
Search for other papers by Jurek Pietrzak in
Google Scholar
PubMed
haematoma from poor haemostasis, or fluid from a deep capsular defect, and must be considered potentially infectious and demands intervention. 11 In PWD, the natural barrier of the skin is bypassed, providing a retrograde pathway for pathogens to enter the
Daniel J. McCormack
Daniel J. McCormack
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
Search for other papers by Daniel J. McCormack in
Google Scholar
PubMed
Search for other papers by Daniel J. McCormack in
Google Scholar
PubMed
Darren Puttock
Darren Puttock
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
Search for other papers by Darren Puttock in
Google Scholar
PubMed
Search for other papers by Darren Puttock in
Google Scholar
PubMed
Steven P. Godsiff
Steven P. Godsiff
Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK
Search for other papers by Steven P. Godsiff in
Google Scholar
PubMed
Search for other papers by Steven P. Godsiff in
Google Scholar
PubMed
revision surgery, those with spine, hip or foot pathology were excluded. Patients with a past history of septic arthritis or previous surgery other than diagnostic arthroscopy were also excluded. Significant patella-femoral joint damage and an inability to
Cheuk Yin Li
Cheuk Yin Li
School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Search for other papers by Cheuk Yin Li in
Google Scholar
PubMed
Search for other papers by Cheuk Yin Li in
Google Scholar
PubMed
Kenneth Jordan Ng Cheong Chung
Kenneth Jordan Ng Cheong Chung
School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Search for other papers by Kenneth Jordan Ng Cheong Chung in
Google Scholar
PubMed
Search for other papers by Kenneth Jordan Ng Cheong Chung in
Google Scholar
PubMed
Omar M. E. Ali
Omar M. E. Ali
School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Search for other papers by Omar M. E. Ali in
Google Scholar
PubMed
Search for other papers by Omar M. E. Ali in
Google Scholar
PubMed
Nicholas D. H. Chung
Nicholas D. H. Chung
School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Search for other papers by Nicholas D. H. Chung in
Google Scholar
PubMed
Search for other papers by Nicholas D. H. Chung in
Google Scholar
PubMed
Cheuk Heng Li
Cheuk Heng Li
School of Medical Education, Newcastle University, Framlington Place, Newcastle upon Tyne, UK
Search for other papers by Cheuk Heng Li in
Google Scholar
PubMed
Search for other papers by Cheuk Heng Li in
Google Scholar
PubMed
that phagocytose any small wear particles < 5 μm in diameter, and this induces the release of interleukin-1ß (IL-1ß) and tumour necrosis factor-α. These stimulate the recruitment and activation of osteoclasts via the RANK-L pathway and thus osteolysis
Sebastian Kopf
Sebastian Kopf
Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany
Search for other papers by Sebastian Kopf in
Google Scholar
PubMed
Search for other papers by Sebastian Kopf in
Google Scholar
PubMed
Manuel-Paul Sava
Manuel-Paul Sava
Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania
Search for other papers by Manuel-Paul Sava in
Google Scholar
PubMed
Search for other papers by Manuel-Paul Sava in
Google Scholar
PubMed
Christian Stärke
Christian Stärke
Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany
Search for other papers by Christian Stärke in
Google Scholar
PubMed
Search for other papers by Christian Stärke in
Google Scholar
PubMed
Roland Becker
Roland Becker
Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany
Search for other papers by Roland Becker in
Google Scholar
PubMed
Search for other papers by Roland Becker in
Google Scholar
PubMed
system, including the pro-inflammatory pathway. 23 Another definition proposed by the American College of Rheumatic and Therapeutic Criteria states that OA is a group of conditions that are heterogenic, which advances to joint-related symptoms and
Alli Gokeler
Alli Gokeler
University of Groningen, University Medical Center Groningen, Center for Human Movement Science, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
Search for other papers by Alli Gokeler in
Google Scholar
PubMed
Search for other papers by Alli Gokeler in
Google Scholar
PubMed
Bart Dingenen
Bart Dingenen
Rehabilitation Research Institute, Biomedical Research Institute, Faculty of Medicine and Life Sciences, UHasselt, Diepenbeek, Belgium
Search for other papers by Bart Dingenen in
Google Scholar
PubMed
Search for other papers by Bart Dingenen in
Google Scholar
PubMed
Caroline Mouton
Caroline Mouton
Département de l’Appareil Locomoteur, Centre Hospitalier de Luxembourg – Clinique d’Eich, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg
Search for other papers by Caroline Mouton in
Google Scholar
PubMed
Search for other papers by Caroline Mouton in
Google Scholar
PubMed
Romain Seil
Romain Seil
Département de l’Appareil Locomoteur, Centre Hospitalier de Luxembourg – Clinique d’Eich, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg and Sports Medicine Research Laboratory, Luxembourg Institute of Health, 76, rue d’Eich, L-1460 Luxembourg, Luxembourg
Search for other papers by Romain Seil in
Google Scholar
PubMed
Search for other papers by Romain Seil in
Google Scholar
PubMed
pathways may be established in individual hospitals or clinics to monitor patients after ACL injury, adapt the care to their individual needs and enhance successful RTS. 11 The work presented in this narrative review is the result of an international
