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Martin McNally
Martin McNally
The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
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Geertje Govaert
Geertje Govaert
Department of Trauma Surgery, University of Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands
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Maria Dudareva
Maria Dudareva
The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
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Mario Morgenstern
Mario Morgenstern
Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland
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Willem-Jan Metsemakers
Willem-Jan Metsemakers
Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium
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randomized trials of fracture fixation used any definition of infection when reporting this complication. 7 By contrast to prosthetic joint infection, the lack of a definition or diagnostic strategy for infection has hampered the development of
Brijesh Ayyaswamy
Brijesh Ayyaswamy
Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK
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Bilal Saeed
Bilal Saeed
Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK
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Anoop Anand
Anoop Anand
Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK
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Lai Chan
Lai Chan
Edge Hill University, Ormskirk, UK
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Vishwanath Shetty
Vishwanath Shetty
Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK
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to neurogenic inflammation. The exact pathway and mechanisms are not known but Janig and Koltzenburg 10 suggested ‘coupling’ of sympathetic and somatic afferent neurons. Mos et al 11 reported that the incidence of CRPS in the general
Martin McNally
Martin McNally
The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
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Irene Sigmund
Irene Sigmund
The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria
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Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria
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Andrew Hotchen
Andrew Hotchen
The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
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Ricardo Sousa
Ricardo Sousa
Porto Bone and Joint Infection Group (GRIP), Department of Orthopaedics, Centro Hospitalar Universitario Santo António and CUF-Hospitais e Clinicas, Portugal
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definition, does not dictate any particular treatment. This can only be decided by combining information from the definition and classification together with a full discussion of the patient’s needs and wishes. The diagnostic pathway is just the start of the
AliSina Shahi
AliSina Shahi
The Rothman Institute at Thomas Jefferson University, Philadelphia, USA
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Javad Parvizi
Javad Parvizi
The Rothman Institute at Thomas Jefferson University, Philadelphia, USA
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protective pathways in the host. Microarray techniques have shown a specific gene expression signature exhibited by the white blood cells (WBCs) in the synovial fluid of infected joints, distinctive of the innate host immune response to infection. 10
Jacobien H.F. Oosterhoff
Jacobien H.F. Oosterhoff
Department of Orthopaedic Surgery, Amsterdam UMC, University of Amsterdam, the Netherlands
Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
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Job N. Doornberg
Job N. Doornberg
Department of Orthopaedic Surgery, Amsterdam UMC, University of Amsterdam, the Netherlands
Department of Orthopaedic & Trauma Surgery, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia
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Department of Orthopaedic & Trauma Surgery, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia
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Machine Learning Consortium
Machine Learning Consortium
Members of the Machine Learning Consortium: Paul Algra, Michel van den Bekerom, Mohit Bhandari, Michiel Bongers, Charles Court-Brown, Anne-Eva Bulstra, Geert Buijze, Sofia Bzovsky, Neil Chen, Job Doornberg, Andrew Duckworth, J. Carel Goslings, Benjamin Gravesteijn, Olivier Groot, Gordon Guyatt, Laurent Hendrickx, Dirk-Jan Hofstee, Frank IJpma, Ruurd Jaarsma, Stein Janssen, Paul Jutte, Aditya Karhade, Lucien Keijser, Gino Kerkhoffs, David Langerhuizen, Jonathan Lans, Wouter Mallee, Matthew Moran, Margaret McQueen, Marjolein Mulders, Miryam Obdeijn, Tarandeep Oberai, Jacobien H.F. Oosterhoff, Rudolf Poolman, David Ring, Paul Tornetta III, Joseph Schwab, Emil H. Schemitsch, Niels Schep, Inger Schipper, Bram Schoolmeesters, Marc Swiontkowski, David Sanders, Sheila Sprague, Ewout Steyerberg, Stephen D. Walter, Monique Walenkamp
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promising results as valuable diagnostic tools to assist clinicians in many respective specialties. As early as the 1980s a data-driven clinical prediction tool to determine which patients with chest pain presenting to the ED (emergency department) could be
T. Fintan Moriarty
T. Fintan Moriarty
AO Research Institute Davos, Switzerland
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Richard Kuehl
Richard Kuehl
University Hospital of Basel, Switzerland
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Tom Coenye
Tom Coenye
Ghent University, Belgium
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Willem-Jan Metsemakers
Willem-Jan Metsemakers
University Hospitals Leuven, Belgium
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Mario Morgenstern
Mario Morgenstern
Trauma Centre, Murnau, Germany
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Edward M. Schwarz
Edward M. Schwarz
University of Rochester Medical Center, New York, USA
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Martijn Riool
Martijn Riool
AMC, University of Amsterdam, The Netherlands
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Sebastian A.J. Zaat
Sebastian A.J. Zaat
AMC, University of Amsterdam, The Netherlands
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Nina Khana
Nina Khana
University Hospital of Basel, Switzerland
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Stephen L. Kates
Stephen L. Kates
Virginia Commonwealth University, Virginia, USA
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R. Geoff Richards
R. Geoff Richards
AO Research Institute Davos, Switzerland
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Propionibacterium (P.) acnes prevalence, at up to 38%. 19 Recently, more attention has been focussed upon polymicrobial infections, which may account for 10%-20% of cases. 13 , 14 , 17 Furthermore, studies using molecular diagnostic techniques indicate
Simon Donell
Simon Donell
University of East Anglia, Faculty of Medicine and Health Sciences - Norwich Medical School, UK
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from a number of different molecular pathways 6 that include matrix metalloproteinases (MMP-1, MMP-13), 7 complement component-5, 8 hypoxia-inducible factor 2α (HIF-2α) 9 , 10 and inhibition of TGF-β signalling. 11 ‘Studies
Shaho Hasan
Shaho Hasan
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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Peter van Schie
Peter van Schie
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Bart L Kaptein
Bart L Kaptein
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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Jan W Schoones
Jan W Schoones
Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands
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Perla J Marang-van de Mheen
Perla J Marang-van de Mheen
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands
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Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands
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Rob G H H Nelissen
Rob G H H Nelissen
Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
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pressure, and endotoxins have been proposed as well ( 14 , 15 , 16 , 17 ). Ultimately, aseptic loosening can be confirmed intraoperatively, but any diagnostic before extensive revision surgery helps in the decision to perform surgery in patients with
Agnieszka Halm-Pozniak
Agnieszka Halm-Pozniak
Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany
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Christoph H Lohmann
Christoph H Lohmann
Department of Orthopaedics, Otto-von-Guericke University Magdeburg, Germany
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Luigi Zagra
Luigi Zagra
IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy
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Benedikt Braun
Benedikt Braun
Department of Trauma and Reconstructive Surgery at the Eberhard Karls University Tübingen, BG Unfallklinik Tübingen, Germany
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Max Gordon
Max Gordon
Department of Clinical Sciences at Danderyd Hospital, Unit of Orthopedics, Karolinska Institutet, Stockholm, Sweden
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Bernd Grimm
Bernd Grimm
Department of Precision Health, Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods, Luxembourg
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. Mantovani A Leopaldi C Nighswander CM & Di Bidino R . Access and reimbursement pathways for digital health solutions and in vitro diagnostic devices: current scenario and challenges . Frontiers in Medical Technology 2023 5 1101476. ( https
Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Sven Geissler
Sven Geissler
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Carsten Perka
Carsten Perka
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Georg N Duda
Georg N Duda
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Alexander Hildebrandt
Alexander Hildebrandt
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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-controlled trial (RCT). Furthermore, successful implementation of advanced therapeutics into orthopaedic practice will mandate advanced diagnostic tools to identify early disease stages and also a deep knowledge of the market dynamics. This review aims to provide
