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Julie J. Willeumier Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Yvette M. van der Linden Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Michiel A.J. van de Sande Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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P.D. Sander Dijkstra Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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by metastases. 39 The mainstay treatment is rigid surgical stabilisation because of a high incidence of nonunion and inadequate relief of pain with conservative treatment. 40 Although the upper extremities are not primarily weight

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Miklós Szendrői Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Imre Antal Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Attila Szendrői Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Áron Lazáry National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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Péter Pál Varga National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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, the time interval between the diagnosis of cancer and that of the metastases (more than three years), additional conservative treatments and type of surgery were also significant factors in cases with solitary metastases. 20 , 24 , 25 In another

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Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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0167-8140(9601856-7 ) 9027935 23. Braschi EL Kharod SM Morris CG Spiguel AR Gibbs CP Scarborough MT & Zlotecki RA . Reirradiation in conservative salvage of recurrent soft-tissue sarcoma: an analysis of treatment efficacy and

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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difficult to remedy. Where there is doubt after initial assessment, this should prompt referral to a specialized tumour centre, where an appropriate biopsy and pre-operative and reconstructive planning should take place prior to undertaking any treatment

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Joaquim Soares do Brito Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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André Spranger Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Paulo Almeida Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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José Portela Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Irene Barrientos-Ruiz Orthopedics Department, University Hospital of La Paz, Madrid

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Wide resection and intralesional resection with curettage are two of the most common options for surgical treatment. When curettage is performed, local adjuvant therapies are often used to reduce the probability of a local recurrence, which is usually

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Chengxiang Li Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
University of Basel, Basel, Switzerland

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Fatime Krasniqi Department of Oncology, University Hospital Basel, Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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Ricardo Donners The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Department of Radiology, University Hospital Basel, Basel, Switzerland

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Christoph Kettelhack The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Clarunis, University Digestive Health Care Center, St. Clara Hospital and University Hospital Basel, Switzerland

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Andreas H Krieg Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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recommending chemotherapy for SS in adults, given that systemic treatment with the combination of doxorubicin and ifosfamide could reduce the risk of distant metastases and that preoperative chemotherapy could increase the probability of conservative resection

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Olga Savvidou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Dimitra Melissaridou First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, LAIKON General Hospital, Athens, Greece
Co-senior authors

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Panayiotis J. Papagelopoulos First Department of Orthopedics, National and Kapodistrian University of Athens, Medical School, ATTIKON University General Hospital, Greece
Co-senior authors

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) Immunohistochemical staining for SATB2, highlighting the large number of osteoblasts in this area. Note . MO, myositis ossificans; H&E, hematoxylin and eosin. Treatment A conservative approach is the treatment of choice, because MO is a self

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Andrea Angelini Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Ivan Bohacek Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Mihovil Plecko Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Carlo Biz Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Mariachiara Cerchiaro Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giuseppe Di Rubbo Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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studies, conservative treatment, curettage and grafting, review articles), or studies not reporting on functional outcomes after surgery. The reviewers independently screened titles and abstracts of all identified studies. Studies were further included in

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Robert Grimer The Royal Orthopaedic Hospital, Birmingham, UK

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Michael Parry The Royal Orthopaedic Hospital, Birmingham, UK

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Steven James The Royal Orthopaedic Hospital, Birmingham, UK

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past many of these patients then had no further treatment but there was a very high rate of local recurrence (up to 70%) and it is now far more common for these patients to be referred to a sarcoma unit for definitive management. 2 In 1994

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