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regarding the clinical efficacy of gene therapy. Conclusions The current methods commonly used clinically to treat osteochondral lesions mainly result in fibrocartilage formation and are only suitable for the treatment of small defects less than 2
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implants. These procedures can be performed arthroscopically, as described previously. 78 Regarding clinical efficacy, good mid-term and long-term clinical outcomes of polyurethane-based scaffolds and CMI were recently reported. 82 - 85 Currently
Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK
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evidence on efficacy is inadequate in quality. NICE recommends that this procedure should only be used with special arrangements for clinical governance, consent, and audit or research. 74 They also suggest that any further research into PRP
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exercise intensities on OA to provide reasonable and feasible exercise parameters for OA patients. It also summarizes substantial clinical randomized controlled trial results of different kinds of exercise to confirm the clinical or daily exercise efficacy
Hospital Sotero del Rio, Santiago, Chile
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Hospital Padre Hurtado, Santiago, Chile
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a contaminated graft could be the main factor in postoperative septic arthritis and in an effort to maximize the antibiotic efficacy on the graft, Vertullo et al in 2012 10 described the Vancomycin presoaking technique. The practice involves
Ripoll y De Prado Sports Clinic, Murcia-Madrid, FIFA Medical Centre of Excellence, Madrid, Spain
International Centre of Sports Traumatology of the Ave, Vila do Conde, Portugal
3Bs Research Group, I3Bs, Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Barco, Guimarães, Portugal
ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clínica do Dragão, Espregueira-Mendes Sports Centre, FIFA Medical Centre of Excellence, Porto, Portugal
Orthopedic Department, University of Minho, Braga, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal
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ICVS/3Bs, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Orthopaedic Department, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, Guimarães, Portugal
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, despite remaining one of the most frequent orthopaedic procedures worldwide. 20 – 24 Meniscus repair commonly provides superior clinical outcomes when compared with meniscectomy. 25 , 26 As a general rule, the meniscus tissue should be preserved
These authors contributed equally to this work
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to its high efficacy and safety. 45 , 46 When MRL is located, the tear is often chosen to be closed. An all-inside suture with hook device remains the most popular choice among surgeons. In case of MRL extending medially into the meniscus, a
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offset and smaller patellar component size. Gholson et al 10 2017 In a series of 1488 TKA cases, 46 (3.1%) patients were identified to have clinical signs and symptoms of PCS during postoperative clinical follow-up. The incidence of PCS