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Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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study of denosumab efficacy and safety in patients with breast cancer-related bone metastases . Journal of Clinical Oncology 2007 25 4431 – 4437 . ( https://doi.org/10.1200/JCO.2007.11.8604 ) 44. Bussiere JL Pyrah I Boyce R Branstetter D

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0138
Volume/Issue:
Volume 8: Issue 12
Open access
Maria Anna Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Joanna Szkandera Division of Clinical Oncology, Internal Medicine, Medical University of Graz, Graz, Austria

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Dimosthenis Andreou Division of Orthopaedic Oncology and Sarcoma Surgery, Helios Klinikum Bad Saarow, Sarcoma Center Berlin-Brandenburg, Berlin, Germany

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Emanuela Palmerini Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna University, Bologna, Italy

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Marko Bergovec Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Graz, Austria

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respective studies. Furthermore, study limitations, levels of evidence according to the Oxford Centre for Evidence Based Medicine Levels of Evidence Scale, 10 and clinical efficacy in distinct histological subtypes were documented. Fig. 1 PRISMA

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.5.200069
Volume/Issue:
Volume 5: Issue 11
Open access
Elisa Pala Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Maria Chiara Cerchiaro Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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or opening of the medullary canal) ( 7 ). When this is not performed, the success rate decreases to 62% ( 3 ). Bone substitute materials seem to be the most effective for filling the cavity, with an efficacy of 87% despite autograft (63%) and

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-24-0027
Volume/Issue:
Volume 9: Issue 5
Open access
Maria Anna Smolle Medical University of Graz, Austria

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Dimosthenis Andreou Münster University Hospital, Germany

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Per-Ulf Tunn Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Germany

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Joanna Szkandera Medical University of Graz, Austria

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Bernadette Liegl-Atzwanger Medical University of Graz, Austria

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Andreas Leithner Medical University of Graz, Austria

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Soft-tissue swellings, lumps and bumps are frequently seen in routine clinical practice. However, with an estimated annual incidence of five cases per 100 000 people in Europe, soft-tissue sarcomas (STS) are relatively rare and are outnumbered by

Article Type:
Research Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.2.170005
Volume/Issue:
Volume 2: Issue 10
Open access
Irina-Anca Eremia Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Mihnea Popa Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Adela Iancu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Silvia Nica Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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1960s, are pivotal in treating malignancies like RCC due to their ability to inhibit osteoclasts and slow bone loss. Their safety and efficacy have been supported by clinical trials, showing notable reductions in skeletal-related events (SREs) such as

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0178
Volume/Issue:
Volume 9: Issue 6
Open access
Chengxiang Li Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
University of Basel, Basel, Switzerland

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Fatime Krasniqi Department of Oncology, University Hospital Basel, Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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Ricardo Donners The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Department of Radiology, University Hospital Basel, Basel, Switzerland

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Christoph Kettelhack The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland
Clarunis, University Digestive Health Care Center, St. Clara Hospital and University Hospital Basel, Switzerland

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Andreas H Krieg Department of Orthopedic, University Children´s Hospital (UKBB), Basel, Switzerland
The Bone and Soft Tissue Tumor Center of the University of Basel (KWUB), Basel, Switzerland

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, affecting pediatric, adolescent, and adult populations. The peak incidence is observed in the third decade of life. The inconspicuousness and diversity of early symptoms and the rarity of SSs pose a certain influence on patient presentation and clinical

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0193
Volume/Issue:
Volume 9: Issue 3
Open access
Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, Mediterraneo Hospital, Athens, Greece

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Ioanna K. Bolia First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Angelos Kaspiris Laboratory of Molecular Pharmacology/Sector for Bone Research, School of Health Sciences, University of Patras, Patras 26504, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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, although the clinical presentation of the most frequent lesions might be straightforward, it can often be difficult to differentiate benign and reactive lesions from malignant and aggressive ones on purely clinical grounds. Thus, it is important for the

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.4.190002
Volume/Issue:
Volume 4: Issue 12
Open access
Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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of clinical efficacy and quality assessment of reported trials . Journal of Surgical Oncology 2012 106 921– 928 . ( https://doi.org/10.1002/jso.23200 ) 22806575 39. Movva S Wen W Chen W Millis SZ Gatalica Z Reddy S von Mehren M

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0095
Volume/Issue:
Volume 8: Issue 8
Open access
James Plant Royal National Orthopaedic Hospital, Stanmore, UK

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Stephen Cannon Royal National Orthopaedic Hospital, Stanmore, UK

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-S , et al. . The clinical efficacy of (18)F-FDG-PET/CT in benign and malignant musculoskeletal tumors . Ann Nucl Med 2008 ; 22 : 603 - 9 . 9 Dimitrakopoulou-Strauss A , Strauss LG , Heichel T , et al. . The role

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.1.000035
Volume/Issue:
Volume 1: Issue 6
Open access
Stephanie Marrannes Department of Orthopedic Surgery, Ghent University, Belgium

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Klaas Victor Department of Orthopedic Surgery, University of Leuven, Belgium

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Nele Arnout Department of Orthopedic Surgery, Ghent University, Belgium

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Tine De Backer Department of Cardiology, Ghent University, Belgium

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Jan Victor Department of Orthopedic Surgery, Ghent University, Belgium

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Thomas Tampere Department of Orthopedic Surgery, Ghent University, Belgium

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patients with radiographic examination or ultrasound on a set date, whereas other studies performed imaging based on clinical suspicion. This caused large discrepancies in reported VTE incidences between studies screening for asymptomatic or symptomatic

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1302/2058-5241.6.200120
Volume/Issue:
Volume 6: Issue 10
Open access