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were used: ‘(tendon OR tendinopathy OR tendinitis OR tendinosis OR disorder OR injury OR rupture OR treatment) AND (achilles) AND (quinolon* OR fluoroquinolon* OR ciprofloxacin OR fleroxacin OR enoxacin OR norfloxacin OR ofloxacin OR levofloxacin OR
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-negative Enterobacteriaceae (E. coli, Klebsiella, Enterobacter etc.) - Ciprofloxacin 750 mg, every 12 h p.o. Nonfermenteres (Pseudomonas aeruginosa, Acinetobacter spp.) 2–3 weeks: - Piperacillin/tazobactam or - Meropenem or - Ceftazidim + - Tobramycin or
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proliferation, slowing growth. 45 Ciprofloxacin has also been shown to cause growth retardation in children, 46 although its effects may not be clinically significant. 47 Diabetes, 48 hypothyroidism, 49 and renal failure 15 have
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be challenging. 22 With reference to ODRI, bacteria resistant to the few antibiotics with proven anti-biofilm activity (Rifampicin-resistant staphylococci and ciprofloxacin-resistant Gram-negatives) are among the most difficult pathogens to treat
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susceptibility to antibiotics used for treatment of PJI remained largely unchanged, including rifampicin, daptomycin and vancomycin against gram-positive bacteria or ciprofloxacin, meropenem and ceftazidime against gram-negative bacteria. Table 2. Number of
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with levofloxacin, ciprofloxacin or amoxicillin (8.3%) or monotherapy with linezolid or cotrimoxazole (0%). 76 Esteban et al stated that the ideal oral antibiotic must be intracellularly effective, with pharmacokinetic properties similar to that of
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and ciprofloxacin . Antimicrob Agents Chemother 2003 ; 47 : 1251 – 1256 . 11. Gbejuade HO Lovering AM Webb JC . The role of microbial biofilms in prosthetic joint infections . Acta Orthop 2015 ; 86 : 147
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al. . Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy . Arthritis Rheum 2002 ; 46 : 3034 - 3040
King’s Global Health Partnerships, School of Life Course and Population Sciences, King’s College London, London, UK
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from India ( 44 ) reports isolates from 100 patients being predominantly Staphylococcus aureus . Of concern, they note 75% of isolates were resistant to gentamicin, 81% to ciprofloxacin and 50% were methicillin-resistant Staphylococcus aureus (MRSA
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fenestrated and necrotic bone sequestra excised. Suction drain placed in remaining gutter. Dead space obliterated with free muscle transfer. IV ciprofloxacin given at time of surgery and then orally for 6 weeks post-operatively. If microbiology culture and
