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J R W Crutsen Department of Orthopaedic Surgery, VieCuri Medical Center, Venlo, the Netherlands

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M C Koper Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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J Jelsma Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands

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M Heymans Zuyderland Academy, Centre of Knowledge and Information (KIC), Zuyderland Medical Centre, Sittard-Geleen, the Netherlands

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I C Heyligers Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Health Professions Education (SHE), Maastricht University, Maastricht, the Netherlands

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B Grimm Luxembourg Institute Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg

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N M C Mathijssen Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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M G M Schotanus Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands

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debris (ARMD) ( 1 , 2 , 3 , 4 ). There is also an increasing number of case reports describing systemic reactions in relation to elevated blood cobalt concentrations known as prosthetic hip-associated cobalt toxicity (PHACT) ( 5 , 6 ). Increased

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Konrad Sebastian Wronka Department Of Orthopaedics, Prince Philip Hospital, Hywel Dda University Healthboard, Llanelli, UK

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Michell Gerard-Wilson Department Of Orthopaedics, Prince Philip Hospital, Hywel Dda University Healthboard, Llanelli, UK

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Elizabeth Peel Department Of Orthopaedics, Prince Philip Hospital, Hywel Dda University Healthboard, Llanelli, UK

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Ola Rolfson Department Of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden

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Peter Herman Johan Cnudde Department Of Orthopaedics, Prince Philip Hospital, Hywel Dda University Healthboard, Llanelli, UK
Department Of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden

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was popularized by Sir John Charnley for use in low-friction arthroplasty in the 1960s. 9 , 10 However, Charnley described a 4.2% non-union rate in his case series of 379 THAs in 1972. 11 Current literature reports the non-union rate

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Yun Yang Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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Yin-xiao Peng Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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Bin Yu Department of Orthopaedics, The Third People’s Hospital of Chengdu, Sichuan, PR China

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and outcomes of patients with simultaneous pelvic or acetabular and ipsilateral femoral fractures ( 2 , 3 , 12 ). At present, there are few relevant studies on this injury, and most of them are case reports ( 13 , 14 , 15 , 16 , 17 , 18 , 19

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Filippo Maria Anghilieri Residency Program in Orthopaedics and Traumatology, School of Medicine and Surgery, University of Milan, Milan, Italy

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Ilaria Morelli U.O.C. Ortopedia e Traumatologia, ASST Ovest Milanese, Nuovo Ospedale di Legnano, Legnano, Milano, Italy

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Giuseppe M Peretti IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

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Fabio Verdoni IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Domenico Curci IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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with contralateral hip prophylactic fixation. Letters to the editor, reviews, editorials, case reports and unpublished articles were excluded. Search strategy and study selection We conducted a comprehensive literature search using PubMed

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Andy Craig Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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S W King Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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B H van Duren Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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V T Veysi Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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S Jain Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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J Palan Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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primary arthroplasty) registered in the NJR since 2003, infection is given as the indication for 9.8 and 16.1% of cases for THA and TKA, respectively ( 6 ). PJI can thus be considered as a major cause for revision surgery and has long been reported as such

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Jonathan M. R. French Bristol Royal Infirmary, University Hospitals Bristol NHS Trust, Bristol, UK

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Paul Bramley Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Sean Scattergood Bristol Royal Infirmary, University Hospitals Bristol NHS Trust, Bristol, UK

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Nemandra A. Sandiford Southland Teaching Hospital, Invercargill, New Zealand

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analysis, case reports, review articles, expert opinion pieces, biomechanical studies, animal studies, in vitro studies, book chapters, conference abstracts, and non-English-language articles. In cases of multiple articles reporting on the same patient

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Eustathios Kenanidis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece
Hôpital de la Tour, Geneva, Switzerland

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Konstantinos Kapriniotis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panagiotis Anagnostis Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Michael Potoupnis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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Panayiotis Christofilopoulos Hôpital de la Tour, Geneva, Switzerland

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Eleftherios Tsiridis Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Hellas, Greece
Center of Orthopaedics and Regenerative Medicine (C.O.RE.) – Center of Interdisciplinary Research and Innovation (C.I.R.I.) – Aristotle University Thessaloniki, Balkan Center, Hellas, Greece

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– 13 , 15 – 23 reported on the type of implant fixation; there were 437 cemented, 520 cementless and five hybrid THAs; nine cases were unspecified. The majority of studies published before 2010 reported on cemented THAs but afterward this date only

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Riccardo D’Ambrosi IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Nicola Ursino IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

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Carmelo Messina IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy

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Federico Della Rocca Istituto Clinico Humanitas, Rozzano, Italy

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Michael Tobias Hirschmann Department of Orthopaedic Surgery and Traumatology Kantonsspital Baselland (Bruderholz, Liestal, Laufen) Switzerland

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A flowchart of the literature screening performed in this study. Eligibility and exclusion criteria In this systematic review, studies of level I, II, III, IV and case reports were included. The assessment of the level of evidence of the

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Stavros Tsotsolis Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
Department of Trauma and Orthopaedics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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evaluating the THA survival; (ii) were narrative reviews, case series and reports, letters to the editor or editorial comments; (iii) were conducted in animals or cadavers; (iv) were written in a non-English language; (v) had no full-text available

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Mattia Loppini Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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Francesco Manlio Gambaro Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

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Rob G H H Nelissen Landelijke Registratie Orthopedische Implantaten (Dutch Arthroplasty Register), ’s Hertogenbosch, The Netherlands
Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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Guido Grappiolo IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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://www.ncbi.nlm.nih.gov/books/NBK507864/ ) 2 Evans JT Evans JP Walker RW Blom AW Whitehouse MR Sayers A . How long does a hip replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up . Lancet

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