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Mattia Loppini Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona - Università degli Studi di Genova, Via Magliotto 2, Savona, Italy

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Francesco Manlio Gambaro Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, Italy

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Marco di Maio Università degli Studi di Trieste, Piazzale Europa 1, Trieste, Italy

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Guido Grappiolo IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona - Università degli Studi di Genova, Via Magliotto 2, Savona, Italy

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defects need to be addressed. Although more severe bone loss patterns have variable amounts of diaphysis remaining, the femoral revision aims to obtain a proper primary stability of the stem with a more proximal fixation as possible to preserve and if

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Thorsten Gehrke Department of Orthopaedic Surgery, Helios ENDO-Klinik, Hamburg, Germany

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Mustafa Citak Department of Orthopaedic Surgery, Helios ENDO-Klinik, Hamburg, Germany

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Mustafa Akkaya Department of Orthopaedic Surgery, Helios ENDO-Klinik, Hamburg, Germany

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solutions in adequately addressing extensive bone defects and achieving stable fixation ( 19 , 20 ). Many patients face the risk of severe bone loss or PD due to repeated acetabular revision surgeries ( Fig. 1 ) ( 4 ). However, it is possible to achieve

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Luca Pierannunzii Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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Luigi Zagra Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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Introduction Bone loss is a major concern of revision total hip arthroplasty (THA). While on the femoral side the problem is commonly solved by passing the defect through long stems seeking distal fixation in the healthy diaphysis, on the

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George C. Babis 2nd Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Konstantopouleio Hospital, Greece

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Vasileios S. Nikolaou 2nd Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Konstantopouleio Hospital, Greece

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bone loss) and type IVc (PD + previous irradiation of the pelvis with or without cavity or segmental bone loss). 4 In other widely used classifications, such as that of Paprosky et al, PD can be seen in type IIC and IIIA defects but are more

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Pengqiang Lou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Guangzhi Zhou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Bo Wei Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Xiaolei Deng Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Decai Hou Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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bone regeneration in rabbit skull defects . BMC Musculoskeletal Disorders 2013 14 76. ( https://doi.org/10.1186/1471-2474-14-76 ) 39. Li P Ma YC Sheng XY Dong HT Han H Wang J & Xia YY . Cyclic fluid shear stress promotes

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Demien Broekhuis Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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Rutger Tordoir Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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Zoe Vallinga Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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Jan Schoones Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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Bart Pijls Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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Rob Nelissen Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands

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and AAOS type 3 and 4 defects demonstrate severe bone loss of the acetabular rim and supporting structures, such as the medial wall and the anterior/posterior column with possible pelvic discontinuity ( 1 , 2 , 3 ). Over the past decades, multiple

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Giorgio Maria Calori ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Emilio Mazza ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Alessandra Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Simone Mazzola ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Massimiliano Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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long bone nonunion and bone defects as evidenced by many studies. 52 - 58 Their application in cases of AVN of FH may give similar good results. Further studies are needed to clarify the more effective biotechnologies to use in the treatment of

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Bengt Mjöberg Department of Orthopaedics, Lund University, Lund, Sweden

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pressure from the gap between the stem and the cement through a defect in the cement mantle. The pressure waves may devitalize the adjacent bone tissue, which is resorbed, thereby causing focal femoral osteolysis. Note . From Acta Orthop 31 with

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Adrian J. Cassar-Gheiti Cappagh National Orthopaedic Hospital, Dublin, Ireland

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Rosie McColgan Galway University Hospital, Galway, Ireland

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Martin Kelly Connolly Hospital, Orthopaedic Department, Dublin, Ireland

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Theresa M. Cassar-Gheiti Cappagh National Orthopaedic Hospital, Dublin, Ireland

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Paddy Kenny Cappagh National Orthopaedic Hospital, Dublin, Ireland
Connolly Hospital, Orthopaedic Department, Dublin, Ireland

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Colin G. Murphy Galway University Hospital, Galway, Ireland

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MS et al. Safety, osseointegration, and bone ingrowth analysis of PMMA-based porous cement on animal metaphyseal bone defect model . J Biomed Mater Res B Appl Biomater 2018 ; 106 : 649 – 658 . 20. Cimatti B Engel EE

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James R Satalich VCU Health Department of Orthopaedic Surgery, Richmond, Virginia, USA

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Daniel J Lombardo VCU Health Department of Orthopaedic Surgery, Richmond, Virginia, USA

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Simon Newman Nuffield Orthopaedic Center, University of Oxford, Oxford, UK

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Gregory J Golladay VCU Health Department of Orthopaedic Surgery, Richmond, Virginia, USA

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Nirav K Patel VCU Health Department of Orthopaedic Surgery, Richmond, Virginia, USA

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result in improved penetration into the macrostructure of cancellous bone, resulting in stronger fixation ( 10 , 11 ). Centralizers are primarily aimed to decrease the incidence of C2 defects on the Barrack classification where the implant is in direct

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