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Xiang-Dong Wu Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Yixin Zhou Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Hongyi Shao Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Dejin Yang Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Sheng-Jie Guo Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Wei Huang Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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type IIIB), so a customized augment was designed to fill the bone defect ( 25 ). They suggested that robotic-assisted technology minimized bone loss as only one acetabular reaming was required with accurate preoperative planning and robot arm

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Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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augment healing ( 3 ). Within trauma, there are a number of indications for bone graft, spanning from acute use for traumatic bone defects, as part of staged bone defect management such as that achieved with the masquelet technique, to augment stability

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Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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26% have been also claimed for iliac crest autograft ( 31 ). In the presence of bone defects, the bone regeneration may not be obtained from bone graft unless there is an active biological surrounding, and this relates to the study and development of

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Heinz Winkler Osteitis Centre, Privatklinik Döbling Wien, Heiligenstaedter Strasse 57-63, A-1190 Wien, Austria

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external fixators for stabilisation. Bone defects 5 After removal of infected implants and radical sequestrectomy, bony defects will always be present. There are several suggestions as to how to address this issue; what all have in common is the

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Simon Donell University of East Anglia, Faculty of Medicine and Health Sciences - Norwich Medical School, UK

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subchondral plate is seen macroscopically as a chondral defect. Breeching of the subchondral plate coupled with the chondral damage allows the movement of fluid, cells and molecules between the bone and the joint cavity. Mechanical forces can also affect and

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Maria-Pau Ginebra Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Montserrat Espanol Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Yassine Maazouz Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain
Mimetis Biomaterials, Spain

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Victor Bergez Mimetis Biomaterials, Spain

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David Pastorino Mimetis Biomaterials, Spain

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previous section, bone has the capacity to regenerate in specific circumstances. However, this capacity is not unlimited; it is restricted to small bone defects. There is no biological mechanism for large-scale repair of bone. This is the case, for example

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Michalis Panteli Academic Department of Trauma & Orthopaedics, Leeds General Infirmary; School of Medicine, University of Leeds, UK

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Peter V. Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary; School of Medicine, University of Leeds, UK

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small defects / limited availability of bone graft - Risk of early resorption / highly depends on the soft tissue bed - Risk of relapse of infection - Graft incorporation is slow and unreliable - Donor site morbidity Antibiotic-impregnated cement

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Razvan Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Dragos Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Adrian Cursaru Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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space’ and, when needed, provide reconstruction material for bone defects. Based on their characteristics the two main categories of materials used for local antibiotic treatment are non-degradable and biodegradable. The most prevalent non

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Zaki Arshad University of Cambridge School of Clinical Medicine, Cambridge, UK

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Edward Jun-Shing Lau University of Cambridge School of Clinical Medicine, Cambridge, UK

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Aiman Aslam University of Cambridge School of Clinical Medicine, Cambridge, UK

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Azeem Thahir Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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Matija Krkovic Department of Trauma and Orthopaedic Surgery, Addenbrooke’s Hospital, Cambridge, UK

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drainage. Antibiotic bone cement consisting of vancomycin-loaded poly(methyl methacrylate) inserted into defect. Post-operative antibiotic treatment for 6 weeks. Lidgren 1980 37 Intramedullary reaming in all. Closed intramedullary suction

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Christoph H. Lohmann Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Sanjiv Rampal Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Martin Lohrengel Department of Orthopeadic Surgery, Otto-von-Guericke University, Leipziger Str. 44,39120 Magdeburg, Germany

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Gurpal Singh Division of Musculoskeletal Oncology, University Orthopaedics Hand and Reconstructive Microsurgery Cluster, National University Health System, 1E Kent Ridge Road, 119228 Singapore

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failure mechanisms in order to prevent it from happening again. Implant type, position and stability need to be determined and any defects in the bone and soft tissue should be noted. It goes without saying that detected abnormalities based on imaging

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