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Giorgio Perino Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Ivan De Martino Division of Orthopaedics and Traumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

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Lingxin Zhang Department of Pathology and Laboratory Medicine, Sinai Health System, Toronto, Canada

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Zhidao Xia Centre for Nanohealth, Swansea University Medical School, Singleton Park, Swansea, UK

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Jiri Gallo Department of Orthopaedics, Faculty of Medicine and Dentistry, University Hospital, Palacky University Olomouc, Czech Republic

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Shonali Natu Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK

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David Langton Orthopaedic Department, Freeman Hospital, Newcastle upon Tyne, UK

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Monika Huber Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Wien, Austria

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Anastasia Rakow Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Janosch Schoon Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Enrique Gomez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Veit Krenn MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik-GmbH, Trier, Germany

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lymphocytic-dominated vasculitis associated lesion (ALVAL), 20 later expanded to adverse local tissue reactions (ALTR) 21 and adverse reactions to metal debris (ARMD) 22 associated with metal-on-metal (MoM) hip resurfacing arthroplasty (HRA) and

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