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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xuelei Zhang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chengxin Xie Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Department of Endocrinology, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Luxia Wu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Guoping Cai Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Introduction Spinal surgery necessitates the peeling of soft tissues such as muscles from around the vertebral bodies, while fusion surgery also necessitates the opening of the laminae and removal of the intervertebral discs from the affected

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chaojun Shen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Tongyou Qu Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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Lin Chen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yue Sun Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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recommendations for spine surgeons (including those in orthopedics and brain or neurosurgery). Any intraspinal misuse of TXA into the cerebrospinal fluid or topical application of TXA during spinal surgery is likely to result in seriously adverse consequences once

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Scott D. Middleton Scott D. Middleton, Department of Orthopaedic Surgery, The Royal Infirmary and University of Edinburgh, United Kingdom

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Ralf Wagner Ralf Wagner, Ligamenta Spine Centre, Frankfurt am Main, Germany

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J. N. Alastair Gibson J. N. Alastair Gibson, Department of Orthopaedic Surgery, The Royal Infirmary and University of Edinburgh, United Kingdom

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herniated disc from inside the spinal canal. Evidence supporting minimally invasive approaches and transforaminal endoscopic spinal surgery (TESS) in particular has grown exponentially over the last ten years. In this review, the authors describe the

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Wai Weng Yoon Spinal Surgery Unit, University Hospitals of Leicester NHS Trust, Leicester, UK
Centre for Spinal Surgery, Queens Medical Centre, Nottingham University NHS Trust, Nottingham, UK

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Jonathan Koch Centre for Spinal Surgery, Queens Medical Centre, Nottingham University NHS Trust, Nottingham, UK

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  • In all levels of disc herniations the absolute surgical indications include deteriorating neurological deficits with myelopathy or cauda equina syndrome. However, this review summarized the relative indications for surgery in each level.

  • In cervical disc herniation (CDH), the indications for surgery consist of six months of persisting symptoms, not responding to conservative treatment. However, high-quality studies are lacking, and a randomized controlled trial is now underway to clarify the indications.

  • In thoracic disc herniation (TDH), the indications for surgery comprise failure of conservative measures and/or worsening neurological symptoms. Moreover, giant calcified thoracic disc herniations or myelopathy signs on magnetic resonance imaging, even in the absence of neurological symptoms, may benefit from surgical treatment as a preventive measure.

  • In lumbar disc herniation (LDH), the indications for surgery include imaging confirmation of LDH, consistent with clinical findings, and failure to improve after six weeks of conservative care.

Cite this article: EFORT Open Rev 2021;6:526-530. DOI: 10.1302/2058-5241.6.210020

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Qiushi Bai Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Yuanyi Wang Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China

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Jiliang Zhai Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Jigong Wu Chinese People’s Liberation Army Strategic Support Force Characteristic Medical Center, Beijing, China

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Yan Zhang Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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Yu Zhao Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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symptoms, compression location, and cord priority, non-spinal factors also determine the surgical strategy of TSS. With the exacerbation of the aging society, the elderly account for a large proportion of patients who undergo spinal surgery ( 97 ). The high

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Mirza Biscevic Department of Orthopedics, General Hospital Sarajevo, Bosnia and Herzegovina

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Aida Sehic Department of Intraoperative Neurophysiologic Monitoring, SMS, Louisville, Kentucky, USA

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Ferid Krupic Department of Orthopedics, Sahlgrenska Academy at University of Gothenburg, Sweden

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group of 1121 MEP/SSEP-monitored scoliosis surgeries, although the relevant signal changes were noted in 3.4% surgeries. 39 IONM significantly decreases risk in spinal surgeries, and today it is the standard of care in the US and many other

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Han Zhang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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mechanism of action is to reduce bleeding by inhibiting the production and activity of plasmin, thereby preventing the dissolution of fibrin. Previous meta-analyses have evaluated the safety and efficacy of tranexamic acid in spinal surgery. Based on a

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Paulo Diogo Cunha Orthopedic Surgery Department, Hospital de Braga, Portugal

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Tiago P Barbosa Orthopedic Surgery Department, Hospital de Braga, Portugal

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Guilherme Correia Orthopedic Surgery Department, Hospital de Braga, Portugal

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Rafaela Silva Anesthesiology Department, Hospital de Braga, Portugal

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Nuno Cruz Oliveira Orthopedic Surgery Department, Hospital de Braga, Portugal

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Pedro Varanda Orthopedic Surgery Department, Hospital de Braga, Portugal
Life and Health Science Research Institute, University of Minho, Portugal

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Bruno Direito-Santos Orthopedic Surgery Department, Hospital de Braga, Portugal
Life and Health Science Research Institute, University of Minho, Portugal

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shunt of blood flow through the epidural and paravertebral veins, which increases the pressure in the epidural venous circuit, augmenting the bleeding in the surgical field during spinal surgery. Abdominal compartment syndrome is also a potential

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Rory D. S. Gibson Aberdeen Royal Infirmary, Aberdeen, UK

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Ralf Wagner Ligamenta Spine Centre, Frankfurt am Main, Germany

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J. N. Alastair Gibson The Royal College of Surgeons of Edinburgh, Edinburgh, UK

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-thoracotomy or a retropleural approach have both been recommended, 64 modern advancements in imaging, coupled with laser resection, may now allow surgeons to consider full endoscopy for even these difficult pathologies. During any spinal surgery

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Junbo He Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China
These authors contributed equally to this work and should be considered co-first authors

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Tingkui Wu Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China
These authors contributed equally to this work and should be considered co-first authors

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Chen Ding Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China

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Beiyu Wang Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China

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Ying Hong West China School of Nursing, Sichuan University/ Department of Anesthesia and Operation Center, West China Hospital, Sichuan University, Chengdu, China

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Hao Liu Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China

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cervical arthrodesis Hilibrand, AS 975 44.3 IV 4 A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned Carragee, EJ 898 89.8 NA 5 Donor site

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