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Daniel J. McCormack Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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Darren Puttock Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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Steven P. Godsiff Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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Introduction Many patients present to orthopaedic surgeons with a painful knee attributed to osteoarthritis of the medial compartment, where the lateral compartment and patella-femoral joint are relatively spared. Traditionally, the treatment

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Julien Favre Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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Brigitte M. Jolles Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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Introduction Osteoarthritis (OA), the most common type of arthritis, is a disease causing pain, deformity, and dysfunction of the joints. This condition affects a constantly increasing portion of the population, inducing serious socio

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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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Introduction Osteoarthritis (OA) is a degenerative disease with a tendency to worsen over time, characterized by articular cartilage degradation, subchondral damage, and bone remodelling, most commonly affecting weight-bearing joints such as

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Sebastian Kopf Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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Manuel-Paul Sava Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania

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Christian Stärke Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany

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Roland Becker Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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osteoarthritis (OA). This close relationship between menisci and articular cartilage has also been demonstrated through the impact of degenerative and trauma-related meniscal injuries on the articular cartilage. 7 – 9 Both cartilage and meniscus lesions

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David T. Wallace Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK
Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, UK

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Philip E. Riches Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK

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Frédéric Picard Department of Biomedical Engineering, University of Strathclyde, Glasgow, UK
Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, UK

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form conclusions as to the biomechanical nature of self-reported instability and to suggest further direction for research to produce a quantifiable marker for knee instability. PubMed and Medline searches using the terms ‘knee’, ‘osteoarthritis

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Gareth G. Jones MSk Lab, Imperial College London, London, UK

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Martin Jaere MSk Lab, Imperial College London, London, UK

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Susannah Clarke MSk Lab, Imperial College London, London, UK

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Justin Cobb MSk Lab, Imperial College London, London, UK

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Introduction High tibial osteotomy (HTO) is typically used to treat early isolated medial tibiofemoral compartment osteoarthritis in younger, and physically active, patients for whom knee arthroplasty is associated with higher revision rates

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Gareth G. Jones MSk Lab, Imperial College London, UK.

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Susannah Clarke MSk Lab, Imperial College London, UK.

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Martin Jaere MSk Lab, Imperial College London, UK.

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Justin Cobb MSk Lab, Imperial College London, UK.

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Introduction Osteoarthritis (OA) is an important cause of disability in both the United Kingdom and United States, representing a significant individual and socioeconomic burden. 1 – 3 The knee joint is most commonly affected (termed

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Andrea Ferrera Department of Orthopaedic and Traumatology, Orthopaedic and Trauma Centre, Turin, Italy

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Jacques Menetrey Centre de Médecine du Sport et de l’Exercice (CMSE), Swiss Olympic Medical Center, Hirslanden Clinique La Colline, Geneva, Switzerland
Division of Orthopaedic Surgery, University Hospital of Geneva, Geneva, Switzerland

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Introduction The history of osteotomies starts in the 16th century, but the real development of these techniques has improved between the 19th and 21st centuries, to become the gold standard treatment for the unicompartmental osteoarthritis of

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, “Infanta Elena” University Hospital, Valdemoro, Madrid, Spain
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain

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E Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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. Knee stiffness Acute infection Chronic infection (osteomyelitis) Malunion Non-union Post-traumatic osteoarthritis Residual knee instability secondary to ligaments damage that was not addressed initially, during

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Introduction Total knee arthroplasty (TKA) has proven to be a successful, safe and cost-effective treatment in the management of advanced osteoarthritis. The incidence of TKA has increased steadily in the last decade and is expected to

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