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Simon Donell
Simon Donell
University of East Anglia, Faculty of Medicine and Health Sciences - Norwich Medical School, UK
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Introduction Subchondral bone is the bedrock of a joint on which sits the articular cartilage. Traditionally, osteoarthritis (OA) has been considered to be wear and tear of articular cartilage, but more recent evidence has shown that
Hamid Rahmatullah Bin Abd Razak
Hamid Rahmatullah Bin Abd Razak
Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
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Sengkang General Hospital, Singapore
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Daniel Chew
Daniel Chew
Faculty of Medicine, Imperial College London, London, UK
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Zepur Kazezian
Zepur Kazezian
Department of Bioengineering, Imperial College London, London, UK
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Anthony M.J. Bull
Anthony M.J. Bull
Department of Bioengineering, Imperial College London, London, UK
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Introduction Osteoarthritis (OA) is a global disease with a variety of pathophysiological factors. 1 These factors can be mechanical, biological or a combination of both. Cardinal features of OA include loss of joint space and cartilage
Di Zhao
Di Zhao
The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Ling-feng Zeng
Ling-feng Zeng
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Gui-hong Liang
Gui-hong Liang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Jian-ke Pan
Jian-ke Pan
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Ming-hui Luo
Ming-hui Luo
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Yan-hong Han
Yan-hong Han
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Jun Liu
Jun Liu
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
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Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
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Wei-yi Yang
Wei-yi Yang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Introduction Osteoarthritis (OA) is a severe and painful joint disease that limits daily activities and reduces quality of life. OA is estimated to be the third leading cause of disability, affecting approximately 350 million people worldwide
Thomas Collins
Thomas Collins
Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK
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Dinesh Alexander
Dinesh Alexander
Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK
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Bilal Barkatali
Bilal Barkatali
Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK
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can have negative effects such as pro-inflammatory cytokines, matrix metalloproteinases (MMPs) and interleukin-1β (IL-1β). 48 For example, Browning et al 49 demonstrated an increase in MMP-1 and MMP-3 in osteoarthritis (OA) synoviocytes
Michael Beverly
Michael Beverly
Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford
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David W Murray
David W Murray
Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford
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been little further interest. While research into osteoarthritis has focused mainly on cartilage and synovium at the mechanical, macroscopic, microscopic, cellular, molecular and genetic levels, subchondral vascular aspects have escaped attention ( 12
Mara Meyer Günderoth
Mara Meyer Günderoth
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Alexandra Bannach-Brown
Alexandra Bannach-Brown
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany
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Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Johannes Keller
Johannes Keller
Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Robert Karl Zahn
Robert Karl Zahn
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Introduction Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common forms of arthritis and affect large parts of the global population. While both diseases share some phenotypical similarities (joint swelling and stiffness
Myles C Murphy
Myles C Murphy
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
School of Health Sciences and Physiotherapy, The University of Notre Dame Australia, Fremantle, Western Australia, Australia
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School of Health Sciences and Physiotherapy, The University of Notre Dame Australia, Fremantle, Western Australia, Australia
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Christopher Latella
Christopher Latella
School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Ebonie K Rio
Ebonie K Rio
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
Australian Ballet, Southbank, Victoria, Australia
Victorian Institute of Sport, Albert Park Victoria, Australia
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Australian Ballet, Southbank, Victoria, Australia
Victorian Institute of Sport, Albert Park Victoria, Australia
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Janet L Taylor
Janet L Taylor
School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Stephanie Martino
Stephanie Martino
Cubus Physio Zug, Zug, Switzerland
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Colin Sylvester
Colin Sylvester
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
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William Hale
William Hale
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
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Andrea B Mosler
Andrea B Mosler
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
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La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
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Introduction Osteoarthritis (OA) is a leading cause of pain and disability globally ( 1 ). It results in substantial health expenditure in Australia, with over $3.5 billion being spent annually on OA burden ( 2 ). OA presents as pain and
E Carlos Rodríguez-Merchán
E Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
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Alberto D Delgado-Martínez
Alberto D Delgado-Martínez
Department of Orthopaedic Surgery, Hospital Universitario de Jaén, Jaén, Spain
Department of Surgery, University of Jaén, Jaén, Spain
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Department of Surgery, University of Jaén, Jaén, Spain
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Javier De Andrés-Ares
Javier De Andrés-Ares
Department of Anesthetics, Pain Unit, La Paz University Hospital, Madrid, Spain
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under imaging guidance (fluoroscopy, ultrasonography, and computed tomography) ( 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ). Upper limb RF treatments RF in shoulder osteoarthritis Tran et al . employed image-guided axillary
E. Carlos Rodríguez-Merchán
E. Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain
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aggressively treated to prevent chondrocyte apoptosis and progression to synovitis, recurrent joint bleeds and ultimately end-stage osteoarthritis. These joint bleeds need the following: deficient factor intravenous replacement to 50%; joint aspiration to
Bernd Grimm
Bernd Grimm
AHORSE Research Foundation, Zuyderland Medical Center, Heerlen, The Netherlands.
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Stijn Bolink
Stijn Bolink
AHORSE Research Foundation, Zuyderland Medical Center, Heerlen, The Netherlands.
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been identified”. 3 Another review studied twelve PROMs for the assessment of physical activities in osteoarthritis (OA) patients and concluded that there is “not enough evidence for any instrument to have adequate measurement properties”. 4
