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Current indications for denosumab in benign bone tumours

Antal Imre

Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán

Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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, and

Szendrői Miklós

Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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. They pointed out that denosumab inhibits osteoclast-like giant cells and probably alters the phosphorylation profiles of receptor tyrosine kinases and downstream signalling proteins in the tumourous tissue. Furthermore they performed an off-label