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Alan G. Fraser Department of Cardiology, University Hospital of Wales, Cardiff, UK

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Rob G.H.H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

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Per Kjærsgaard-Andersen Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark

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Piotr Szymański Centre of Postgraduate Medical Education, MSWiA Central Clinical Hospital, Warsaw, Poland

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Tom Melvin Healthcare Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Ireland

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Paul Piscoi Health Technology Unit B6, Directorate General for Health (DG SANTE), European Commission, Brussels, Belgium

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On behalf of the CORE–MD Investigators (see Appendix) Alan Fraser, Piotr Szymański, Chris Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard-Andersen, Rob Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer, Berthold Koletzko, Sarah Wieczorek, Adamos Hadjipanayis, Stefano Del Torso, Perla Marang-van de Mheen, Lotje Hoogervorst, Ewout W. Steyerberg, Bas Penning De Vries, Peter McCulloch, Martin Landray, Daniel Prieto Alhambra, James Smith, Anne Lubbeke-Wolf, Stefan James, Sergio Buccheri, Robert Byrne, Laurna McGovern, Stephan Windecker, Andre Frenk, Georgios Siontis, Christoph Stettler, Arjola Bano, Lia Bally, Frank E. Rademakers, Jan D‘hooge, Anton Vedder, Elisabetta Biasin, Erik Kamenjasevic, Petra Schnell-Inderst, Felicitas Kühne, Ola Rolfson, Joel Jakobsson, Amanda Tornsö, Enrico G. Caiani, Lorenzo Gianquintieri, Cinzia Cappiello, Maristella Matera, Tom Melvin, Niall MacAleenan, Ria Mahon, Michèle Meagher, Gearóid McGauran, Thomas Wejs Møller, Ann-Sofie Sonne Holm-Schou, Jan Szulc, Robert E. Geertsma, Jantine W.P.M. van Baal, Joëlle M. Hoebert, Susana L.F. Cabaço, Paola Laricchiuta, Marina Torre, Filippo Boniforti, Eugenio Carrani, Stefania Ceccarelli, Claudia Wild, Sabine Ettinger, Juan Antonio Blasco Amaro, Juan Carlos Rejón Parrilla, Agnieszka Dobrzynska, David Epstein, Valentina Strammiello, Hannes Jarke, Kaisa Immonen, Françoise Schlemmer, Sabina Hoekstra, Marianna Mastroroberto, Christoph Ziskoven, Michael Hahn, Erman Melikyan, Richard Holborow, Suzanne Halliday, Alexey Shiryaev, Gero Viola, Harry van Vugt

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-points and mandated post-marketing studies. 36 Most had not been approved for children. 37 Off-label drug use in children is associated with adverse events 38 and risks may also occur from off-label use of devices. In CORE–MD, the evaluation of evidence

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.6.210081
Volume/Issue:
Volume 6: Issue 10
Open access
Xiang-Dong Wu Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Yixin Zhou Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Hongyi Shao Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Dejin Yang Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Sheng-Jie Guo Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Wei Huang Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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-of-the-art. Of note, the FDA has currently approved robotic-assisted technology for primary joint arthroplasty, including unicompartmental knee arthroplasty (UKA), THA, and TKA; the technique described here represents an off-label indication. This study was not

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-22-0105
Volume/Issue:
Volume 8: Issue 1
Open access
M M Morlock Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany

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E Gomez-Barrena Department of Orthopaedic Surgery and Traumatology, Universidad Autónoma de Madrid, Madrid, Spain

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D C Wirtz Department of Orthopaedics and Traumatology, University Hospital Bonn, Bonn, Germany

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A Hart London Implant Retrieval Centre, Royal National Orthopaedic Hospital, Stanmore, UK

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J P Kretzer Department of Orthopaedic Surgery, Heidelberg University Hospital, Heidelberg, Germany

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retrieved implants collection and analysis In 2020, the European Federation of Orthopaedics and Traumatology (EFORT) launched an Implant & Patient Safety Initiative addressing the introduction of innovation, the off-label use and mix and match of

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-22-0033
Volume/Issue:
Volume 7: Issue 6
Open access
Bart G. Pijls Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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Jennifer M. T. A. Meessen Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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Keith Tucker Implant Performance Committee, England and Wales National Joint Registry, ODEP, Beyond Compliance and MHRA Expert Advisory Group for MoM Prostheses, London, UK

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Susanna Stea Istituto Ortopedico Rizzoli, Bologna, Italy

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Liza Steenbergen Dutch Arthroplasty Register (Landelijke Registratie Orthopedische Implantaten, LROI), 's- Hertogenbosch, The Netherlands

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Anne Marie Fenstad The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway

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Keijo Mäkelä Department of Orthopedics and Traumatology, Turku University Hospital, Turku, Finland

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Ioan Cristian Stoica Foisor Orthopaedics Clinical Hospital, Bucharest, Romania

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Maxim Goncharov VJRR, Russian Scientific Research Institute of Traumatology and Orthopedics, St Petersburg, Russia

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Søren Overgaard Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark

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Jorge Arias de la Torre Departament de Salut, Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Barcelona, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Instituto de Biomedicina (IBIOMED). Universidad de León, León, Spain

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Anne Lübbeke Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals, Geneva, Switzerland
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

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Ola Rolfson Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Rob G. H. H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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expect surgeons to use all components of the same manufacturer, almost all included registries report off-label mix-and-match prostheses, except for the GAR. The NAR and RAR reported that these mix-and-match prostheses consist of the use of BHR acetabular

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.4.180078
Volume/Issue:
Volume 4: Issue 6
Open access
Razvan Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Dragos Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Adrian Cursaru Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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antibiotic delivery system based on bioactive glass. Until solid data are provided by research into this synthetic biomaterial as an antibiotic delivery system its use for this purpose remains experimental and off-label. 31 – 34 Calcium phosphate

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.6.200083
Volume/Issue:
Volume 6: Issue 5
Open access
Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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off-label, BMPs have also been investigated in the management of critical bone defects. In a canine ulna model, Salkeld et al. were able to demonstrate that the combination of Rh-BMP 7 with either autograft or allograft lead to faster times to union

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-23-0047
Volume/Issue:
Volume 8: Issue 5
Open access