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surgeons have the capacity to adapt their practice when they think it is necessary and go ‘off-label’. EFORT consider these issues extremely important; they are all about patient safety which is why they commissioned this appraisal in order to evaluate all
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. They pointed out that denosumab inhibits osteoclast-like giant cells and probably alters the phosphorylation profiles of receptor tyrosine kinases and downstream signalling proteins in the tumourous tissue. Furthermore they performed an off-label
Hospital Sotero del Rio, Santiago, Chile
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Hospital Padre Hurtado, Santiago, Chile
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Vancomycin presoaked grafts returned to their pre-injury sport compared to their control counterparts. Another important concern are the legal implications involved in this off-label clinical use of Vancomycin. The World Health Organization guideline
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Clinic of Orthopaedic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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stimulates bone formation by activating osteoblasts. PTH (1-84) has shown the same effect and has been used as an osteoporotic treatment as well. 5 This suggests a positive influence on bone healing, and teriparatide has been used off-label for treatment
These authors contributed equally to this work and should be considered co-first authors
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These authors contributed equally to this work and should be considered co-first authors
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cervical spine Robinson, RA 294 5.0 IV 19 A review of the clinical side effects of bone morphogenetic protein-2 James, AW 293 58.6 NA 20 Increased swelling complications associated with off-label usage of rhBMP-2 in the
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-points and mandated post-marketing studies. 36 Most had not been approved for children. 37 Off-label drug use in children is associated with adverse events 38 and risks may also occur from off-label use of devices. In CORE–MD, the evaluation of evidence
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-of-the-art. Of note, the FDA has currently approved robotic-assisted technology for primary joint arthroplasty, including unicompartmental knee arthroplasty (UKA), THA, and TKA; the technique described here represents an off-label indication. This study was not
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retrieved implants collection and analysis In 2020, the European Federation of Orthopaedics and Traumatology (EFORT) launched an Implant & Patient Safety Initiative addressing the introduction of innovation, the off-label use and mix and match of
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include distal humeral non-union after a failed attempted ORIF. Relatively preserved cartilage on the radial head and proximal ulna is a pre-requisite for the use of elbow HA. Surgeons should be aware that elbow HA for any indication is an off-label use of
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. 69 Pertaining to foot and ankle surgery, a novel off-label use of Cerament has been described in a series (Level IV) by Karr, 71 in which vancomycin-impregnated Cerament beads were implanted successfully in the management of patients with