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over the past decade has found that tissue concentrations for systemic antibiotic administration do not always meet the minimum inhibitory concentration (MIC) for effective prevention ( 1 ). Intraosseous (IO) techniques were originally used for fluid
IRCCS Humanitas Research Hospital, Milan, Italy
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therapy should be proposed with caution, especially when adopting biologic products, and further data should be collected before endorsing its routine application. Subchondral injections Subchondral injections refer to minimally invasive intra-osseous
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Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland
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. Therefore, no complications occurring after the 3 months period were recorded ( 66 ). Polacek et al. examined the outcome of 39 patients after a day-case HTO procedure using intraosseous PEEK (polyether ether ketone) implants with KOOS and found a steady
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initially suggested, with compromised microcirculation to the subchondral bone resulting in oedema and increased intra-osseous pressure, finally leading to ischaemia and ON. 40 However, the evidence in favour of this theory is limited to a small number