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thromboprophylaxis following major orthopaedic surgery is recommended by most guidelines and is widely accepted as the gold standard. 8 , 9 The 2012 American College of Chest Physicians (ACCP) guideline suggests that low molecular weight heparin (LMWH), fondaparinux
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hyperhydration and calcitonin is preferred ( 50 ). Unfortunately, there is no guideline regarding optimal dose, duration and interval for denosumab treatment in children. Some authors used standard doses and interval treatment for adolescents over 15 years of age
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. Management of metastatic disease of the appendicular skeleton . Curr Orthop 2006 ; 20 : 299 - 315 . 6 Shibata H Kato S Sekine I . Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese
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revisited . Cancer 2002 ; 94 : 2511 - 2516 . 63 Kandel R Coakley N Werier J . Surgical margins and handling of soft-tissue sarcoma in extremities: a clinical practice guideline . Curr Oncol 2013 ; 20 : e247 - e254