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Stephanie Marrannes Department of Orthopedic Surgery, Ghent University, Belgium

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Klaas Victor Department of Orthopedic Surgery, University of Leuven, Belgium

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Nele Arnout Department of Orthopedic Surgery, Ghent University, Belgium

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Tine De Backer Department of Cardiology, Ghent University, Belgium

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Jan Victor Department of Orthopedic Surgery, Ghent University, Belgium

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Thomas Tampere Department of Orthopedic Surgery, Ghent University, Belgium

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thromboprophylaxis following major orthopaedic surgery is recommended by most guidelines and is widely accepted as the gold standard. 8 , 9 The 2012 American College of Chest Physicians (ACCP) guideline suggests that low molecular weight heparin (LMWH), fondaparinux

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Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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hyperhydration and calcitonin is preferred ( 50 ). Unfortunately, there is no guideline regarding optimal dose, duration and interval for denosumab treatment in children. Some authors used standard doses and interval treatment for adolescents over 15 years of age

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Miklós Szendrői Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Imre Antal Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Attila Szendrői Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Áron Lazáry National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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Péter Pál Varga National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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. Management of metastatic disease of the appendicular skeleton . Curr Orthop 2006 ; 20 : 299 - 315 . 6 Shibata H Kato S Sekine I . Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese

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Maria Anna Smolle Medical University of Graz, Austria

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Dimosthenis Andreou Münster University Hospital, Germany

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Per-Ulf Tunn Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Germany

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Joanna Szkandera Medical University of Graz, Austria

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Bernadette Liegl-Atzwanger Medical University of Graz, Austria

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Andreas Leithner Medical University of Graz, Austria

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revisited . Cancer 2002 ; 94 : 2511 - 2516 . 63 Kandel R Coakley N Werier J . Surgical margins and handling of soft-tissue sarcoma in extremities: a clinical practice guideline . Curr Oncol 2013 ; 20 : e247 - e254

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