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John-Henry Rhind Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Eamon Ramhamadany Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Ruaraidh Collins Basingstoke and North Hampshire Hospital, Basingstoke, Hampshire, UK

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Siddharth Govilkar Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Debashis Dass Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Stuart Hay Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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if appropriately dealt with by a senior orthopaedic clinician, rather than staff in the ED department. BOAST guidelines were introduced for fracture clinic services in 2013 by the BOA. The most challenging guideline (BOAST 7) stipulated that

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Leonard Christianto Singjie Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Reynaldo Halomoan Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Ifran Saleh Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

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Endrotomo Sumargono Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia

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Erica Kholinne Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia

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scores. A score was given to every paper to classify them as low- or high-quality studies. The level of evidence was assessed using the Oxford Center for Evidence-Based Medicine Guideline 2011 ( 14 ). Data extraction and analysis All data were

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Dieter Wirtz Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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Hendrik Kohlhof Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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several practical guidelines such as the guideline published by the Society for Healthcare Epidemiology of America/Surgical Infection Society/American Society of Health-System Pharmacists/Infectious Diseases Society of America that recommend that pre

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Ricardo Sousa Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal
Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal

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André Carvalho Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Ana Cláudia Santos Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Miguel Araújo Abreu Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Embil JM et al. International Working Group on the Diabetic Foot (IWGDF) Guideline on the diagnosis and treatment of foot infection in persons with diabetes 2019 . https://iwgdfguidelines.org/wp-content/uploads/2019/05/05-IWGDF-infection-guideline

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Elcil Kaya Bicer Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, Izmir, Turkey

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Heiner Fangerau Department of the History, Philosophy and Ethics of Medicine, Heinrich-Heine-Universität Düsseldorf, Germany

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Hakki Sur Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, Izmir, Turkey

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utilization of AI in orthopedics. In 2019, the European Federation of National Associations of Orthopaedics and Traumatology (EFORT) published a guideline on aspects of AI applications in the field of orthopedics and traumatology that warrant ethical

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Claus Varnum The Danish Hip Arthroplasty Register
Department of Orthopaedic Surgery, Vejle Hospital, Vejle, Denmark

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Alma Bečić Pedersen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

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Ola Rolfson The Swedish Hip Arthroplasty Register
Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Cecilia Rogmark The Swedish Hip Arthroplasty Register
Lund University, Skåne University Hospital, Department of Orthopedics, Malmö, Sweden

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Ove Furnes The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Bergen, Norway
Department of Clinical Medicine, University of Bergen, Bergen, Norway

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Geir Hallan The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Bergen, Norway
Department of Clinical Medicine, University of Bergen, Bergen, Norway

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Keijo Mäkelä The Finnish Arthroplasty Register
Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland

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Richard de Steiger Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR), Adelaide, Australia
Department of Surgery, Epworth HealthCare, University of Melbourne, Melbourne, Australia

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Martyn Porter The National Joint Registry of England, Wales, Northern Ireland and Isle of Man
Centre for Hip Surgery, Wrightington Hospital, Wrightington, Wigan and Leigh NHS Trust, Lancashire, United Kingdom

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Søren Overgaard The Danish Hip Arthroplasty Register
Orthopaedic Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark

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: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines . Chest 2012 ; 141 :e278S-e325S. 48. National Clinical Guideline Centre . Acute and chronic conditions

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Hua Luo Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

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Feng Xue Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, People’s Republic of China

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Zhenghua Hong Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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0.7% ( 7 ). Systemic antibiotics were used before surgery, which was recommended by the evidence-based clinical guideline for prophylactic antibiotics in spinal surgery ( 8 ). However, the incidence of SSIs still ranges from 1 to 10%. Once SSIs occur

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Dimitrios A. Flevas First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Evanthia Mitsiokapa First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis Koulouvaris First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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major orthopaedic surgery. In the last 30 years, nine editions of the guidelines have been published from the ACCP, with the most recent in 2012. However, there is a gap between guideline recommendations and clinical practice. A recent review of the

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AliSina Shahi The Rothman Institute at Thomas Jefferson University, Philadelphia, USA

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Javad Parvizi The Rothman Institute at Thomas Jefferson University, Philadelphia, USA

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infection . Clin Orthop Relat Res 2015 ; 473 : 2244 - 2249 . 20 Parvizi J , Della Valle CJ . AAOS Clinical Practice Guideline: diagnosis and treatment of periprosthetic joint infections of the hip and knee . J Am Acad Orthop

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Alan G. Fraser Department of Cardiology, University Hospital of Wales, Cardiff, UK

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Rob G.H.H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

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Per Kjærsgaard-Andersen Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark

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Piotr Szymański Centre of Postgraduate Medical Education, MSWiA Central Clinical Hospital, Warsaw, Poland

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Tom Melvin Healthcare Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Ireland

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Paul Piscoi Health Technology Unit B6, Directorate General for Health (DG SANTE), European Commission, Brussels, Belgium

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On behalf of the CORE–MD Investigators (see Appendix) Alan Fraser, Piotr Szymański, Chris Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard-Andersen, Rob Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer, Berthold Koletzko, Sarah Wieczorek, Adamos Hadjipanayis, Stefano Del Torso, Perla Marang-van de Mheen, Lotje Hoogervorst, Ewout W. Steyerberg, Bas Penning De Vries, Peter McCulloch, Martin Landray, Daniel Prieto Alhambra, James Smith, Anne Lubbeke-Wolf, Stefan James, Sergio Buccheri, Robert Byrne, Laurna McGovern, Stephan Windecker, Andre Frenk, Georgios Siontis, Christoph Stettler, Arjola Bano, Lia Bally, Frank E. Rademakers, Jan D‘hooge, Anton Vedder, Elisabetta Biasin, Erik Kamenjasevic, Petra Schnell-Inderst, Felicitas Kühne, Ola Rolfson, Joel Jakobsson, Amanda Tornsö, Enrico G. Caiani, Lorenzo Gianquintieri, Cinzia Cappiello, Maristella Matera, Tom Melvin, Niall MacAleenan, Ria Mahon, Michèle Meagher, Gearóid McGauran, Thomas Wejs Møller, Ann-Sofie Sonne Holm-Schou, Jan Szulc, Robert E. Geertsma, Jantine W.P.M. van Baal, Joëlle M. Hoebert, Susana L.F. Cabaço, Paola Laricchiuta, Marina Torre, Filippo Boniforti, Eugenio Carrani, Stefania Ceccarelli, Claudia Wild, Sabine Ettinger, Juan Antonio Blasco Amaro, Juan Carlos Rejón Parrilla, Agnieszka Dobrzynska, David Epstein, Valentina Strammiello, Hannes Jarke, Kaisa Immonen, Françoise Schlemmer, Sabina Hoekstra, Marianna Mastroroberto, Christoph Ziskoven, Michael Hahn, Erman Melikyan, Richard Holborow, Suzanne Halliday, Alexey Shiryaev, Gero Viola, Harry van Vugt

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devices. 10 The international guideline concerning good clinical practice (GCP) that is currently under revision “may also be applied to other clinical investigations that may have an impact on the safety and well-being of human subjects” but it was

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