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Önder İ. Kılıçoğlu Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Mehmet Demirel Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Şamil Aktaş Department of Underwater and Hyperbaric Medicine, İstanbul University, Istanbul Faculty of Medicine, Turkey

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that this system is a quick and effective method for debridement. 39 Furthermore, Clostridial collagenase is a novel enzymatic debridement method and that is reported as tolerable and clinically efficacious in achieving a viable wound bed. However

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Christopher J. Pearce Jurong Health Services Pte Ltd, Singapore

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Audrey Tan Jurong Health Services Pte Ltd, Singapore

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treatment . Disabil Rehabil 2008 ; 30 ; 22 : 1666 - 1676 . 83 Chen YJ , Wang CJ , Yang KD , et al. . Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Thekla Antoniadou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Vasilios G. Igoumenou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Georgios N. Panagopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Konstantinos G. Moulakakis Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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George S. Sfyroeras Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Andreas Lazaris Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Its drawbacks are time and financial cost. Enzymatic debridement involves debridement of necrotic tissue by topical enzymes such as streptokinases, trypsin, papain, fibrinolysin-DNase, collagenase, papainurea and streptodornase. These agents are

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