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Mahmut Nedim Doral Hacettepe University, Faculty of Medicine, Department of Orthopaedics and Traumatology, Department of Sports Medicine, Ankara, Turkey

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Onur Bilge Konya N.E. University, Meram Faculty of Medicine, Department of Orthopaedics and Traumatology, Department of Sports Medicine, Konya, Turkey

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Gazi Huri Hacettepe University, Faculty of Medicine, Department of Orthopaedics and Traumatology, Ankara, Turkey

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Egemen Turhan Hacettepe University, Faculty of Medicine, Department of Orthopaedics and Traumatology, Ankara, Turkey

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René Verdonk Ghent University, Faculty of Medicine, Department of Orthopaedics and Traumatology, De Pintelaan, Ghent, Belgium

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implants. These procedures can be performed arthroscopically, as described previously. 78 Regarding clinical efficacy, good mid-term and long-term clinical outcomes of polyurethane-based scaffolds and CMI were recently reported. 82 - 85 Currently

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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regarding the clinical efficacy of gene therapy. Conclusions The current methods commonly used clinically to treat osteochondral lesions mainly result in fibrocartilage formation and are only suitable for the treatment of small defects less than 2

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