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implants. These procedures can be performed arthroscopically, as described previously. 78 Regarding clinical efficacy, good mid-term and long-term clinical outcomes of polyurethane-based scaffolds and CMI were recently reported. 82 - 85 Currently
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regarding the clinical efficacy of gene therapy. Conclusions The current methods commonly used clinically to treat osteochondral lesions mainly result in fibrocartilage formation and are only suitable for the treatment of small defects less than 2