Hua Luo
Hua Luo
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Xuelei Zhang
Xuelei Zhang
Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Chengxin Xie
Chengxin Xie
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Department of Endocrinology, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Luxia Wu
Luxia Wu
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Guoping Cai
Guoping Cai
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yu Ren
Yu Ren
Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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tTXA reduces the amount of bleeding during spinal surgery. Some randomized controlled trials (RCTs) and non-RCTs claim that tTXA reduces blood loss ( 13 , 14 , 15 ). However, tTXA has also been shown to have no significant effect on reducing blood
Hua Luo
Hua Luo
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Xueli Yan
Xueli Yan
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yu Ren
Yu Ren
Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Han Zhang
Han Zhang
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Wenjun Pan
Wenjun Pan
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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during the operation, and the wound bleeding is more ( 4 ). High blood loss not only increases the patient’s need for blood transfusion and prolongs the operation time but can also lead to various postoperative complications such as infection, delayed
Wen-xi Sun
Wen-xi Sun
Guangzhou University of Chinese Medicine, Guangzhou, China
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Hao-nan Liu
Hao-nan Liu
Guangzhou University of Chinese Medicine, Guangzhou, China
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Meng-tong Chen
Meng-tong Chen
Guangzhou University of Chinese Medicine, Guangzhou, China
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Yong-peng Lin
Yong-peng Lin
Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Hong-shen Wang
Hong-shen Wang
Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Bo-lai Chen
Bo-lai Chen
Guangzhou University of Chinese Medicine, Guangzhou, China
Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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follows: (i) postoperative follow-up included at least two of the following reference indicators: operation time, intraoperative blood loss, visual analogue scale (VAS) score, Oswestry disability index (ODI) score, number of complications, intervertebral
Wen-xi Sun
Wen-xi Sun
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Wei-qiang Huang
Wei-qiang Huang
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Hua-yang Li
Hua-yang Li
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Hong-shen Wang
Hong-shen Wang
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Sheng-li Guo
Sheng-li Guo
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Jie Dong
Jie Dong
Huizhou Hospital of Guangzhou University of Chinese Medicine, Huizhou, China
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Bo-lai Chen
Bo-lai Chen
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Yong-peng Lin
Yong-peng Lin
State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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outcome indicators: the number of screws in grade A and grade A + B positions, visual analog scale (VAS) of low back pain and Oswestry disability index (ODI) scores, radiation dose and exposure time, intraoperative blood loss, operating time, and hospital
Miguel Relvas-Silva
Miguel Relvas-Silva
Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal
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NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal
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Bernardo Sousa Pinto
Bernardo Sousa Pinto
MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine, University of Porto, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
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CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
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António Sousa
António Sousa
Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
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Miguel Loureiro
Miguel Loureiro
Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Hospital das Forças Armadas, Porto, Portugal
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Hospital das Forças Armadas, Porto, Portugal
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André Rodrigues Pinho
André Rodrigues Pinho
Department of Orthopaedics and Traumatology, São João Universitary Hospital Centre, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
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Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
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Pedro Pereira
Pedro Pereira
NeuroGen Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Dr. Plácido da Costa, Porto, Portugal
CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
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CINTESIS@RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, Porto, Portugal
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a report of at least one of the following outcomes: operative time, estimated blood loss, post-operative bedtime or hospital length of stay, back or leg pain (assessed through visual analog scale – VAS), disability (assessed through Oswestry
Amer Sebaaly
Amer Sebaaly
Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.
Department of Orthopedic Surgery, Spine Unit, Centre Hospitalier de l’Université de Montréal (CHUM), Canada.
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Department of Orthopedic Surgery, Spine Unit, Centre Hospitalier de l’Université de Montréal (CHUM), Canada.
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Maroun Rizkallah
Maroun Rizkallah
Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.
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Guillaume Riouallon
Guillaume Riouallon
Department of Orthopedic Surgery, Groupe Hospitalier Paris Saint Joseph, France.
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Zhi Wang
Zhi Wang
Department of Orthopedic Surgery, Spine Unit, Centre Hospitalier de l’Université de Montréal (CHUM), Canada.
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Pierre Emmanuel Moreau
Pierre Emmanuel Moreau
Department of Orthopedic Surgery, Groupe Hospitalier Paris Saint Joseph, France.
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Falah Bachour
Falah Bachour
Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.
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Ghassan Maalouf
Ghassan Maalouf
Department of Orthopedic Surgery, Bellevue Medical Center University Hospital, Faculty of Medicine, Saint Joseph University, Lebanon.
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hospitalization cost, including the cost of the osteosynthesis material, with an average gain of €1159.11 per patient. 21 , 28 Another possible advantage of percutaneous fixation is decreased bleeding and operative time. Many authors showed lower blood loss
Hua Luo
Hua Luo
Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Chaojun Shen
Chaojun Shen
Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Tongyou Qu
Tongyou Qu
Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China
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Lin Chen
Lin Chen
Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yue Sun
Yue Sun
Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
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Yu Ren
Yu Ren
Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China
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surgeries. Systemic TXA administered at the outset of surgery reduces intraoperative blood loss and blood loss from drained spaces such as the knee or mediastinum but may be contraindicated in patients with intravascular stents or thrombophilia ( 3
Xun Wang
Xun Wang
Department of Orthopedics, Center for Plastic & Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China
Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Aiqi Zhang
Aiqi Zhang
Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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Wenchao Yao
Wenchao Yao
Department of Orthopaedics, the First People's Hospital of Chun'an County, Hangzhou, Zhejiang, China
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Haiyan Qiu
Haiyan Qiu
Department of Endocrinology, Afliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
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Fabo Feng
Fabo Feng
Department of Orthopedics, Center for Plastic & Reconstructive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China
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clinical outcomes of patients undergoing MIS-TLIF or ALIF for isthmic spondylolisthesis and revision, and found that ALIF only significantly increased operative time and intraoperative blood loss, whereas there was no significant difference in long
Kamil Cagri Kose
Kamil Cagri Kose
Marmara University Faculty of Medicine Department of Orthopedics and Traumatology, Istanbul, Turkey
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Omer Bozduman
Omer Bozduman
Ufuk University Faculty of Medicine Department of Orthopaedics and Traumatology, Ankara, Turkey
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Ali Erkan Yenigul
Ali Erkan Yenigul
Urfa State Hospital Department of Orthopedics and Traumatology, Istanbul, Turkey
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Servet Igrek
Servet Igrek
Marmara University Faculty of Medicine Department of Orthopaedics and Traumatology, Istanbul, Turkey
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, to previous infection, to blood loss and to prolonged operative time. Underlying co-morbidities like insulin-dependent diabetes mellitus and chronic steroid use and the use of TNF alpha-blockers are also important risk factors for infection
Emmanuelle Ferrero
Emmanuelle Ferrero
Service de chirurgie orthopédique, Hôpital européen Georges Pompidou, France, APHP, Université Paris V
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Pierre Guigui
Pierre Guigui
Service de chirurgie orthopédique, Hôpital européen Georges Pompidou, France, APHP, Université Paris V
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may increase perioperative morbidity with longer operative time, blood loss and neurological complications. Fig. 7 Preoperative and one-year postoperative full spine radiographs of a degenerative spondylolisthesis patient treated with L4-L5
