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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Stavros Tsotsolis Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
Department of Trauma and Orthopaedics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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, 15 , 16 , 17 ). On top of that, there is growing interest in the peri- and post- operative use of anti-resorptive therapies, such as bisphosphonates (BPs), to mitigate the risk of THA AL. BPs are the most widely used drugs to treat osteoporosis

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Morten Schultz Larsen Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Introduction The introduction of bisphosphonates into osteoporosis therapy was a great breakthrough, leading to a remarkable reduction of fracture incidence and improvement of prognosis. 1 Since the effect is caused by a reduction of bone

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Bengt Mjöberg Department of Orthopaedics, Lund University, Lund, Sweden

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surgery (due to the surgical trauma or to the heat from curing cement). Interestingly, the resorption of necrotic bone can be pharmacologically inhibited with a bisphosphonate during the healing period, which reduces the early migration 25 and

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Daniel Petek Clinic of Orthopaedics and Trauma Surgery, HFR-Fribourg District Hospitals, Fribourg, Switzerland

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Didier Hannouche Clinic of Orthopaedics and Trauma Surgery, Geneva University Hospitals, Geneva, Switzerland

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Domizio Suva Clinic of Orthopaedics and Trauma Surgery, Geneva University Hospitals, Geneva, Switzerland

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place for HBO therapy in the management of ONFH but further RCTs are required. 39 Bisphosphonates belong to a class of drug that has an effect on bone resorption by preventing the formation of woven bone as they reduce bone turnover and remodelling

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Ashoklal Ramavath Department of Orthopaedic Surgery, Chapel Allerton Hospital, Leeds, UK

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Jonathan N. Lamb Department of Orthopaedic Surgery, Chapel Allerton Hospital, Leeds, UK
University of Leeds, Leeds, UK

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Jeya Palan Department of Orthopaedic Surgery, Chapel Allerton Hospital, Leeds, UK

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Hemant G. Pandit Department of Orthopaedic Surgery, Chapel Allerton Hospital, Leeds, UK
University of Leeds, Leeds, UK

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Sameer Jain Department of Orthopaedic Surgery, Chapel Allerton Hospital, Leeds, UK

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Bisphosphonates are used to treat osteoporosis and whilst they may reduce periprosthetic bone loss following THR, they can lead to atypical PFFs which have higher rates of reoperation and infection. 29 , 30 Parathyroid hormone can increase periprosthetic bone

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Giuseppe Toro Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

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Antimo Moretti Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.

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Marco Paoletta Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.

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Annalisa De Cicco Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.

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Adriano Braile Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.

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Alfredo Schiavone Panni Department of Medical and Surgical Specialties and Dentistry, University of Campania ‘Luigi Vanvitelli’, Naples, Italy.

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handicapped children in Japan . Environ Health Prev Med . 2010 ; 15 : 135 – 140 . 15. Iwamoto J Takeda T Matsumoto H . Efficacy of oral bisphosphonates for preventing hip fracture in disabled patients with neurological

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Akintunde George Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Marianne Ellis Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Harinderjit Singh Gill Department of Mechanical Engineering, University of Bath, Bath, UK

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agents such as simvastatin and bisphosphonates. It is important to achieve the best possible implant osseointegration into the adjacent bone and to ensure therefore long-term implant stability. For this purpose, various pharmacological, biological and

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