Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
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Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
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Department of Trauma and Orthopaedics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
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Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
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, 15 , 16 , 17 ). On top of that, there is growing interest in the peri- and post- operative use of anti-resorptive therapies, such as bisphosphonates (BPs), to mitigate the risk of THA AL. BPs are the most widely used drugs to treat osteoporosis
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Introduction The introduction of bisphosphonates into osteoporosis therapy was a great breakthrough, leading to a remarkable reduction of fracture incidence and improvement of prognosis. 1 Since the effect is caused by a reduction of bone
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surgery (due to the surgical trauma or to the heat from curing cement). Interestingly, the resorption of necrotic bone can be pharmacologically inhibited with a bisphosphonate during the healing period, which reduces the early migration 25 and
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place for HBO therapy in the management of ONFH but further RCTs are required. 39 Bisphosphonates belong to a class of drug that has an effect on bone resorption by preventing the formation of woven bone as they reduce bone turnover and remodelling
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University of Leeds, Leeds, UK
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University of Leeds, Leeds, UK
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Bisphosphonates are used to treat osteoporosis and whilst they may reduce periprosthetic bone loss following THR, they can lead to atypical PFFs which have higher rates of reoperation and infection. 29 , 30 Parathyroid hormone can increase periprosthetic bone
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
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handicapped children in Japan . Environ Health Prev Med . 2010 ; 15 : 135 – 140 . 15. Iwamoto J Takeda T Matsumoto H . Efficacy of oral bisphosphonates for preventing hip fracture in disabled patients with neurological
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agents such as simvastatin and bisphosphonates. It is important to achieve the best possible implant osseointegration into the adjacent bone and to ensure therefore long-term implant stability. For this purpose, various pharmacological, biological and