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. Some of them have been used since the first case and are still used nowadays like bisphosphonates, vitamin D, calcium, corticosteroids and interferon α-2b. Other drugs such as octreotide, bevacizumab, propranolol, cyclophosphamide, vincristine
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
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Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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, Greece, and Japan, and 2 multicenter studies. Comparison with previous studies Our study provides important insights into the treatment of postmenopausal osteoporosis. Our findings suggest that teriparatide is more effective than bisphosphonates in
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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, anterior cruciate ligament transection; b.w., body weight; BP, bisphosphonate; CCL, cranial cruciate ligament; CIA, collagen-induced arthritis; CT, calcitonin; DM, diabetes mellitus; eCT, eel calcitonin; HA, hyaluronic acid; HDF, high-fat diet; i.a., intra
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Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands
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Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands
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surgery as a consequence ( 25 ). Although currently no other treatment besides revision surgery is available for aseptic loosened implants, novel treatments such as minimal invasive refixation using cement injection or drugs such as bisphosphonates to
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yield a sustainable clinical response and bisphosphonates exhibit only partial success in the management of osseous involvement. 12 After the discovery of BRAF V600E mutation in histiocytes in a significant proportion of ECD patients, the BRAF
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such as the anatomical site (e.g. tibia), fracture type (e.g. open tibia fractures, bone loss, high energy trauma with comminution), or local infection. Patients’ habits (smoking/alcohol abuse), medications (e.g. bisphosphonates, chronic NSAIDs), or the
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Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
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of cystine and reducing oxidative stress ( 71 ). Qu et al. demonstrated that after bisphosphonates treatment, F-box protein 9 could act on P53, leading to ubiquitination and degradation of P53 and ultimately inducing ferroptosis in osteoclasts ( 72
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Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China
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Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China
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alterations interfere with bone remodeling, leading to the local loss of bone mass and potentially causing femoral head collapse ( 7 , 8 ). At present, drugs such as bisphosphonates and calcitonin are used to treat early stages of SONFH. Although these drugs