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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Nicolò Mosele Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Elisa Pagliarini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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. Some of them have been used since the first case and are still used nowadays like bisphosphonates, vitamin D, calcium, corticosteroids and interferon α-2b. Other drugs such as octreotide, bevacizumab, propranolol, cyclophosphamide, vincristine

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Djandan Tadum Arthur Vithran Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Anko Elijah Essien Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Masoud Rahmati Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran

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Michael Opoku Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Dong Keon Yon Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea

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Guillermo F López Sánchez Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain

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Ai Koyanagi Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

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Lee Smith Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK

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Jae Il Shin Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

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Wenfeng Xiao Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shuguang Liu Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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Yusheng Li Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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, Greece, and Japan, and 2 multicenter studies. Comparison with previous studies Our study provides important insights into the treatment of postmenopausal osteoporosis. Our findings suggest that teriparatide is more effective than bisphosphonates in

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Mara Meyer Günderoth Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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Alexandra Bannach-Brown Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany

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Johannes Keller Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Robert Karl Zahn Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Tazio Maleitzke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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, anterior cruciate ligament transection; b.w., body weight; BP, bisphosphonate; CCL, cranial cruciate ligament; CIA, collagen-induced arthritis; CT, calcitonin; DM, diabetes mellitus; eCT, eel calcitonin; HA, hyaluronic acid; HDF, high-fat diet; i.a., intra

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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands

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Bart L Kaptein Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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surgery as a consequence ( 25 ). Although currently no other treatment besides revision surgery is available for aseptic loosened implants, novel treatments such as minimal invasive refixation using cement injection or drugs such as bisphosphonates to

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Vasilios G. Igoumenou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Thekla Antoniadou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Greece

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George Agrogiannis Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Greece

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Periklis Foukas Second Department of Pathology, National and Kapodistrian University of Athens, School of Medicine, Greece

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Sotirios G. Papageorgiou Second Department of Internal Medicine, Hematology Unit, National and Kapodistrian University of Athens, School of Medicine, Greece

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yield a sustainable clinical response and bisphosphonates exhibit only partial success in the management of osseous involvement. 12 After the discovery of BRAF V600E mutation in histiocytes in a significant proportion of ECD patients, the BRAF

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Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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such as the anatomical site (e.g. tibia), fracture type (e.g. open tibia fractures, bone loss, high energy trauma with comminution), or local infection. Patients’ habits (smoking/alcohol abuse), medications (e.g. bisphosphonates, chronic NSAIDs), or the

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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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of cystine and reducing oxidative stress ( 71 ). Qu et al. demonstrated that after bisphosphonates treatment, F-box protein 9 could act on P53, leading to ubiquitination and degradation of P53 and ultimately inducing ferroptosis in osteoclasts ( 72

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Yidan Yang Henan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China

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Yi Jian Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China

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Youwen Liu Henan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China
Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China

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Maoxiao Ma Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China

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Jiayi Guo Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China
Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China

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Bin Xu Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, People’s Republic of China

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Chen Yue Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, Henan Province, People’s Republic of China

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alterations interfere with bone remodeling, leading to the local loss of bone mass and potentially causing femoral head collapse ( 7 , 8 ). At present, drugs such as bisphosphonates and calcitonin are used to treat early stages of SONFH. Although these drugs

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