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bisphosphonate in the treatment of acute CN; 96 , 97 however, there is currently no compelling evidence to support the use of bisphosphonate in the medical management of CN. 96 Additionally, it has recently been discovered that the osteoclastogenic
University of Brighton, UK
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Brighton and Sussex Medical Schools, UK
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progression whilst maintaining bony architecture and preventing deformity. Antiresorptive drugs, in the form of oral bisphosphonates or intravenous pharmacological agents such as Pamidronate, have been used for the management of acute Charcot foot. However
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, in some cases, with calcium) in these cases. Further post-operative osteological investigation of bone mineral density by DXA or qCT and of endocrine status is suggested to evaluate whether the addition of bisphosphonates or other medications may be
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fractures. Treatment for manifest osteoporosis includes life style modifications (smoking and alcohol cessation, physical activity), vitamin D and calcium supplementation, and anti-resorptive drugs (bisphosphonates, raloxifene, denosumab). Promising new
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pattern is seen with often marked distension of the bone and thinning of the cortical bone. Conventional radiography and CT typically describe a milky glass-like change. Therapy for fibrous dysplasia is usually conservative. Bisphosphonates may be used if