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Alessandro Bensa Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Alessandro Sangiorgio Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Angelo Boffa Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Manuela Salerno Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Giacomo Moraca Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland

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Giuseppe Filardo Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland

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effective approach among the intra-articular treatment options for knee OA remains debated ( 26 , 27 ). In this scenario, an updated and comprehensive meta-analysis of randomized controlled trials (RCTs) comparing CS injections with HA and PRP approaches

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Silvia Valisena Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Benjamin Azogui Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Rémy S Nizard Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Philippe M Tscholl Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Etienne Cavaignac Department of Orthopaedics, Hôpital Pierre Paul Riquet, CHU Toulouse, Toulouse, France

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Pierre-Alban Bouché Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Didier Hannouche Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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, since their divulgation, new randomized controlled trials have been published, prompting the need to provide an updated summary of available evidence. We conducted a systematic review and NMA on randomized controlled trials (RCT) on patients with knee

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Qiuyuan Wang Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China

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Feng Li Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China

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Yidan Yang Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China

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Chen Yue Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China

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Jiayi Guo Department of Evidence-based Medicine, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China
Department of Bone And Joint Diseases, Luoyang Orthopedic Hospital of Henan Province. Orthopedic Hospital of Henan Province, Luoyang, China

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entails drawing conclusions from meticulously conducted randomized controlled trials (RCTs) and meta-analyses that meet the highest contemporary scientific standards. Thus, we performed a systematic review and meta-analysis of RCTs to evaluate the impact

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Xinhuan Lei Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hailan Yang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hongya Bao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhong Zhu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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-analysis was registered on PROSPERO (registration no.: CRD42022362584). Inclusion criteria This study included randomized controlled trials (RCTs), cohort studies, or case–control studies. The study population comprised patients undergoing TKA. The

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Daniel J. McCormack Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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Darren Puttock Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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Steven P. Godsiff Department of Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester, UK

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arthritis both in terms of clinical and cost effectiveness after comparing UKR to TKR. 15 The inclusion criteria for this multi-centre randomized controlled trial (RCT) were isolated full-thickness cartilage loss of the medial compartment tibia and

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Mark Anthony Roussot Department of Trauma and Orthopaedics, University College London Hospitals, London, UK
Department of Orthopaedic Surgery, University of Cape Town, South Africa

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Georges Frederic Vles Department of Trauma and Orthopaedics, University College London Hospitals, London, UK

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Sam Oussedik Department of Trauma and Orthopaedics, University College London Hospitals, London, UK

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that reported clinical and/or radiological outcomes comparing KA and MA TKA. Case reports, letters, unpublished data, cadaver studies and studies of revision arthroplasty were excluded ( Fig. 3 ). Fig. 3 PRISMA Flow Diagram Note . RCT

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Sohail Nisar Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Academic Department of Trauma and Orthopaedics, LGI, University of Leeds, Leeds, UK
Leeds Teaching Hospitals Trust, UK

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Jeya Palan Leeds Teaching Hospitals Trust, UK

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Charles Rivière MSK Lab - Imperial College London, White City Campus, London, UK
The Lister Hospital, Chelsea Bridge, London, UK
Centre de l’Arthrose - Clinique du Sport, Bordeaux-Mérignac, France

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Mark Emerton Leeds Teaching Hospitals Trust, UK

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Hemant Pandit Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Leeds Teaching Hospitals Trust, UK

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implant with a femoral component that more closely restores the native trochlea anatomy may help improve patient outcomes. 44 , 45 A recent randomized-controlled trial (RCT), however, which also used the Vanguard implant, found no difference in any

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David Constantinescu Department of Orthopaedics, University of Miami, Miami, Florida, USA

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William Pavlis University of Miami Miller School of Medicine, Miami, Florida, USA

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Michael Rizzo Department of Orthopaedics, University of Miami, Miami, Florida, USA

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Dennis Vanden Berge Department of Orthopaedics, University of Miami, Miami, Florida, USA

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Spencer Barnhill Department of Orthopaedics, University of Miami, Miami, Florida, USA

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Victor Hugo Hernandez Department of Orthopaedics, University of Miami, Miami, Florida, USA

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during hospitalization. The Cochrane Risk of Bias in Randomized Trials (RoB 2.0) and Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tools were used to assess for risk of bias in randomized control trials (RCTs) and

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R J M Morrison Northumbria Healthcare NHS Foundation Trust, Ashington, UK
Newcastle University, Newcastle upon Tyne, UK

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W G Fishley Northumbria Healthcare NHS Foundation Trust, Ashington, UK
University of York, York, UK

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K S Rankin Newcastle University, Newcastle upon Tyne, UK
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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M R Reed Northumbria Healthcare NHS Foundation Trust, Ashington, UK
University of York, York, UK

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controlled trial (RCT) comparing a multivitamin tablet to placebo ( 13 ), one was an RCT comparing two different strengths of vitamin D supplementation on two primary endpoints ( 14 ), and the last was a non-randomised prospective cohort study ( 15 ). All

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Hsiao-Yi Cheng Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Chun-Wei Liang School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

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Yu-Hao Lee Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Timporn Vitoonpong Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand

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Chun-De Liao Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan

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Shih-Wei Huang Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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, International Clinical Trials Registry Platform (ICTRP), and International Standard Randomised Controlled Trial Number registry (ISRCTN)) were searched for relevant clinical trials up to February 2024. Randomized controlled trials (RCTs) that examined ( 1 ) the

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