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Markus A. Küper BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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Alexander Trulson BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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Fabian M. Stuby BG Trauma Center, Department for Traumatology, Orthopedics and Surgery, Murnau am Staffelsee, Germany

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Ulrich Stöckle BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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bony fragments with consequent intrapelvic abscess formation, injury of the obturator nerve, major haemorrhage of the genital organs, or open injuries with complicated infections. However, one of the most frequent complications is iatrogenic: when the

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Nicolas de l’Escalopier Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France
Service de Chirurgie Orthopédique, Traumatologie et Chirurgie Réparatrice des Membres, Hôpital d’Instruction des Armées Percy, France

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Marjorie Salga Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Laure Gatin Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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François Genêt Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Philippe Denormandie Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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risks of infection and recurrence. The disease background Two types of central nervous system trauma may lead to the formation of NHO of the hip: traumatic brain injury (TBI) 5 , 6 and spinal cord injury (SCI). 7 Most often, they

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Farhan Syed University Hospital of Coventry & Warwickshire (UHCW), Coventry, UK

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Anthony Ugwuoke Warwick Hospital, Warwick, UK

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important modes of failure. They used the LCS (Low Contract Stress mobile bearing prosthesis) in an initial 19 cases, followed by the Buechel-Pappas design for the remainder. On the contrary, Van Der Heidi et al 35 found infection to be the most

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Peter Richard Almeida University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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Lipalo Mokete University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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Nkhodiseni Sikhauli University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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Ahmad Mota University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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Bayanda Ndindwa University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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Jurek R T Pietrzak University of the Witwatersrand, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

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-operative complications including but not limited to periprosthetic joint infection (PJI), aseptic loosening, periprosthetic fracture, dislocation, anaemia, prolonged length of stay (LOS), and TJA 90-day total cost, and an increase in mortality ( 7 , 8 , 12 , 13 , 14

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Mark D Kohn Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, Washington, USA

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Charles J Wolock Department of Biostatistics, University of Washington, Seattle, Washington, USA

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Isaac J Poulson School of Medicine, University of Washington, Seattle, Washington, USA

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Navin D Fernando Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, Washington, USA

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infection (PJI), can carry significant morbidity to patients and cost the healthcare system hundreds of millions of dollars per year. ( 4 ) Moreover, TJA requires the manual manipulation of sharp boney surfaces and instruments which can lead to high rates of

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Stavros Tsotsolis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece
Trauma and Orthopaedics Department, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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year of publication restrictions were applied. The primary outcomes were the rate of postoperative complications in patients undergoing TJA with thyroid dysfunction. These were divided into four categories: implant-related, blood loss, infection, and

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Ahmed Fikry Elmenshawy Department of Orthopaedic Surgery, RWTH Aachen University, Aachen, Germany

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Khaled Hamed Salem Department of Orthopaedic Surgery, RWTH Aachen University, Aachen, Germany
Department of Orthopaedic Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt

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hospital stay, postoperative myocardial infarction, postoperative pneumonia, pulmonary embolism, postoperative infection, dislocation rate, heterotopic ossification and postoperative thigh pain. Statistical significance was set at a p-value of p ≤ 0.05 with

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Hua Luo Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Graduate Student Training Base, Jinzhou Medical University, Jinzhou, China

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Liang Ding Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Haijun Xiao Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Ming Wu Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Feng Xue Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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) patients with open fractures at their first injury; (2) pathological fractures; (3) suspected underlying infection; and (4) trials with animal studies or biomechanical studies. Risk of bias assessments Two investigators (Luo and Su) independently

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George C. Babis 2nd Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Konstantopouleio Hospital, Greece

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Vasileios S. Nikolaou 2nd Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Konstantopouleio Hospital, Greece

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recognize pre-existing problems such as infection, excessive bone loss, neurovascular dysfunction, malignancy, irradiation therapy, almost guarantees future complications and failures. Not recognizing the existence or the intraoperative iatrogenic creation

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Anoop Prasad Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Richard Donovan Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Manoj Ramachandran Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Sebastian Dawson-Bowling Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Steven Millington Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Rej Bhumbra Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Pramod Achan Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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Sammy A. Hanna Trauma and Orthopaedic Surgery Department, Royal London Hospital, UK

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novo setting. The virus is spread via the faeco-oral route and infects the central nervous system. Spread occurs via the bloodstream or by retrograde axonal transport to the central nervous system. The infection is most frequently subclinical, but

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