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Tommaso Bonanzinga Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Matteo Carlo Ferrari Humanitas Clinical and Research Center, Milan, Italy

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Piergiuseppe Tanzi IRCCS Istituto Ortopedico Rizzoli; Università di Bologna, Dipartimento Scienze Biomediche e Neuromotorie, Bologna, Italy

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Filippo Vandenbulcke Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Akos Zahar Helios ENDO-Klinik, Hamburg, Germany

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Maurilio Marcacci Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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. Frozen sections are not routinely performed in hospitals, and synovial fluid white blood cell count and differential white blood cell count, while easy to collect in the case of the knee, are sometimes difficult or unreachable in the hip. 6 – 12

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Dimitrios A. Flevas First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Evanthia Mitsiokapa First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis Koulouvaris First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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interesting and useful to apply in clinical practice. Risk factors for VTE There have been many reported risk factors for VTE and recurrent VTE. According to SIGN (2010): 16 1) risk factors for VTE include age, obesity, varicose veins, family

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Martin McNally The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Geertje Govaert Department of Trauma Surgery, University of Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands

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Maria Dudareva The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Mario Morgenstern Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland

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Willem-Jan Metsemakers Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium

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-related infection (FRI) has been published. In 1996, Arens et al reported that in all studies they had reviewed, the term ‘infection’ was not defined. 6 This situation remained unchanged for 22 years when, in 2018, Metsemakers et al found that only 2% of

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Anne Lübbeke Division of Orthopaedic Surgery and Traumatology, Geneva University Hospitals and University of Geneva, Switzerland
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

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James A. Smith Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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Daniel Prieto-Alhambra Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK

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Andrew J. Carr Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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-determinant of the patient’s outcome, which does not apply to drug treatment. In case of a severe complication, surgery may be needed to remove the device with the second operation carrying generally more risk. Moreover, a medical device often remains in, and may

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Mara Meyer Günderoth Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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Alexandra Bannach-Brown Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany

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Johannes Keller Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Robert Karl Zahn Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Tazio Maleitzke Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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RA. Methods This systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA; ( 34 )) and Collaborative Approach to Meta-Analysis and Review of Animal Data

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SaTia T. Sinclair Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, Ohio, United States

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Ahmed K. Emara Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, Ohio, United States

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Melissa N. Orr Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, Ohio, United States

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Kara M. McConaghy Case Western Reserve University School of Medicine, Cleveland, Ohio, United States

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Alison K. Klika Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, Ohio, United States

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Nicolas S. Piuzzi Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, Ohio, United States

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Introduction Total joint arthroplasty is a common surgical procedure worldwide, with more than 1 million total hip arthroplasties (THAs) performed globally each year and several countries reporting nearly 100,000 annual total knee

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Leonard Christianto Singjie Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Reynaldo Halomoan Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Ifran Saleh Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

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Endrotomo Sumargono Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia

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Erica Kholinne Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia

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study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines ( 13 ). The study protocol was registered with PROSPERO (ID: CRD42022299742). The patient, intervention, comparison

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Bowen Lai Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Heng Jiang Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Yuan Gao Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China

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Xuhui Zhou Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China

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many later studies. In 1905, Morgan found the formation of osseous in muscle after injury and named the phenotype as traumatic MO ( 24 ). In 1982, FOP and its characteristic imaging manifestations were reported, and then the number of case reports and

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Hamid Rahmatullah Bin Abd Razak Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
Joint first authors

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Daniel Chew Faculty of Medicine, Imperial College London, London, UK
Joint first authors

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Zepur Kazezian Department of Bioengineering, Imperial College London, London, UK

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Anthony M.J. Bull Department of Bioengineering, Imperial College London, London, UK

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stimulates production of more inflammatory cytokines. This results in progressive cartilage degeneration, causing advanced OA. 4 , 5 In the literature, the prevalence of OA ranges from 12.3% (self-reported in the ‘Disability-Health’ 2009 population

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T Gosens Department of Orthopedic and Trauma Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands
Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands
Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands

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B L den Oudsten Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands
Center of Research on Psychological and Somatic disorders (CoRPS), Tilburg University, Tilburg, The Netherlands

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patients’ self-reported (i.e. subjective) measures about their health status (HS). The possibility of climbing stairs in case of knee or hip problems may be considered as a measure of HS because it is the opinion of the patient about their capability. HS

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